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3,4,5-Trimethoxybenzoic acid

Name: 3,4,5-Trimethoxybenzoic acid
Brand: TargetMol
SKU: T0632
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0632Cas No. 118-41-2

Alias Tri-O-methylgallic acid, Trimethylgallic Acid, Gallic acid trimethyl ether, Eudesmic acid

3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) are potent antioxidants and inhibitor of cytokine production. It can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice. It also exerts hepatoprotective effects in CCl4-induced rats, specifically by modulating oxidative-nitrosative stress and inflammation.

3,4,5-Trimethoxybenzoic acid

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Purity: 99.85%

Catalog No. T0632Alias Tri-O-methylgallic acid, Trimethylgallic Acid, Gallic acid trimethyl ether, Eudesmic acidCas No. 118-41-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

3,4,5-Trimethoxybenzoic acid AI Summary

3,4,5-Trimethoxybenzoic acid exhibits a variety of bioactivities across different biological systems. It shows antimicrobial activity against several fungal strains, including Candida albicans, Aspergillus fumigatus, and Trichophyton rubrum, with a Minimum Inhibitory Concentration (MIC) greater than 250.0 ug/mL, indicating moderate to weak antifungal efficacy. Additionally, it has demonstrated inhibition of HP1-beta chromodomain interactions with methylated histone tails and has induced DNA re-replication in MCF 10a normal breast cells, with potencies of 44668.4 nM and 259.3 nM, respectively. In assays targeting the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1), the compound had an IC50 greater than 67541.0 nM. 3,4,5-Trimethoxybenzoic acid also exhibits strong nematicidal activity against Heterodera zeae larvae, achieving high mortality rates up to 100% at concentrations ranging from 0.125% to 1% under both dark and light conditions. Furthermore, it shows antagonist activity at TLR2 in mouse RAW264.7 cells, inhibiting PAM3CSK4-induced NO production with an IC50 value of 53800.0 nM. Finally, in human TAS2R39 assay tests using HEK293 cells, the compound inhibited epicatechin gallate-induced intracellular calcium release by 20.0%. These diverse bioactivities highlight its potential for multiple therapeutic and agricultural applications, though further studies are necessary to fully understand its mechanisms and optimize its efficacy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) are potent antioxidants and inhibitor of cytokine production. It can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice. It also exerts hepatoprotective effects in CCl4-induced rats, specifically by modulating oxidative-nitrosative stress and inflammation.
Synonyms	Tri-O-methylgallic acid, Trimethylgallic Acid, Gallic acid trimethyl ether, Eudesmic acid

Chemical Properties

Molecular Weight	212.2
Formula	C₁₀H₁₂O₅
Cas No.	118-41-2
Smiles	COC1=CC(=CC(OC)=C1OC)C(O)=O
Relative Density.	1.3006 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (235.63 mM), Sonication is recommended.

Ethanol: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7125 mL	23.5627 mL	47.1254 mL	235.6268 mL
5 mM	0.9425 mL	4.7125 mL	9.4251 mL	47.1254 mL
10 mM	0.4713 mL	2.3563 mL	4.7125 mL	23.5627 mL
20 mM	0.2356 mL	1.1781 mL	2.3563 mL	11.7813 mL
50 mM	0.0943 mL	0.4713 mL	0.9425 mL	4.7125 mL
100 mM	0.0471 mL	0.2356 mL	0.4713 mL	2.3563 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc