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(S,R,S)-AHPC-PEG3-N3

🥰Excellent
Catalog No. T17909Cas No. 1797406-80-4
Alias VHL Ligand-Linker Conjugates 8, VH032-PEG3-N3, E3 ligase Ligand-Linker Conjugates 12

(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

(S,R,S)-AHPC-PEG3-N3

(S,R,S)-AHPC-PEG3-N3

🥰Excellent
Purity: 98.83%
Catalog No. T17909Alias VHL Ligand-Linker Conjugates 8, VH032-PEG3-N3, E3 ligase Ligand-Linker Conjugates 12Cas No. 1797406-80-4
(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
Pack SizePriceAvailabilityQuantity
2 mg$31In Stock
5 mg$48In Stock
10 mg$74In Stock
25 mg$126In Stock
50 mg$188In Stock
100 mg$269In Stock
200 mg$429In Stock
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Purity:98.83%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
In vitro
(S,R,S)-AHPC-PEG3-N3 is derived from patent WO/2016/146985A1, figure 11. PROTAC features an A-L-B structure that tethers a bromodomain inhibitor, binding a BET family protein, to a small molecule E3 ubiquitin ligase protein binding ligand via a suitable linker[1][2].
SynonymsVHL Ligand-Linker Conjugates 8, VH032-PEG3-N3, E3 ligase Ligand-Linker Conjugates 12
Chemical Properties
Molecular Weight645.77
FormulaC30H43N7O7S
Cas No.1797406-80-4
SmilesC([C@@H](NC(COCCOCCOCCN=[N+]=[N-])=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1
Relative Density.no data available
ColorYellow
AppearanceOil
Storage & Solubility Information
Storagestore at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (77.43 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5485 mL7.7427 mL15.4854 mL77.4269 mL
5 mM0.3097 mL1.5485 mL3.0971 mL15.4854 mL
10 mM0.1549 mL0.7743 mL1.5485 mL7.7427 mL
20 mM0.0774 mL0.3871 mL0.7743 mL3.8713 mL
50 mM0.0310 mL0.1549 mL0.3097 mL1.5485 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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Keywords

VHLLigandforE3LigaseLigand for E3 LigaseInhibitorinhibitE3LigaseLigandLinkerConjugateE3 Ligase Ligand-Linker ConjugatesE3 Ligase Ligand-Linker ConjugateE3 Ligase LigandLinker ConjugateAHPC-PEG3-N3(S,R,S)-AHPC-PEG-3-N3(S,R,S)AHPCPEG3N3(S,R,S) AHPC PEG3 N3
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