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(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $219 | In Stock | |
5 mg | $548 | In Stock | |
10 mg | $792 | In Stock | |
25 mg | $1,220 | In Stock | |
50 mg | $2,380 | In Stock |
Description | (Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat. |
In vivo | In anesthetized guinea pigs, (Rac)-Modipafant(UK-74505) at 30 and 100 μg/kg intravenously inhibited the bronchoconstrictor response to aerosolized PAF without affecting blood pressure or heart rate; oral (Rac)-Modipafant(UK-74505) inhibited the increase in permeability of rat skin vessels to intradermal PAF with an ED50 of 280 +/- 5 μg/kg; and in conscious dogs, complete inhibition of PAF-induced whole blood aggregation occurred in vitro for at least 14 hours following an oral dose of (Rac)-Modipafant(UK-74505)(75 μg/kg).[2] |
Alias | UK-74505, UK74505, UK 74505, Modipafant racemate |
Molecular Weight | 605.09 |
Formula | C34H29ClN6O3 |
Cas No. | 122956-68-7 |
Smiles | O=C(OCC)C1=C(NC(=C(C(=O)NC2=NC=CC=C2)C1C=3C=CC=CC3Cl)C)C=4C=CC(=CC4)N5C(=NC=6C=NC=CC65)C |
Relative Density. | 1.34g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (66.11 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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