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(+)-JQ1 PA

Name: (+)-JQ1 PA
Brand: TargetMol
SKU: T17311
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17311Cas No. 2115701-93-2

(+)-JQ1 PA, a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, exhibits an IC50 of 10.4 nM.

(+)-JQ1 PA

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Purity: 98.36%

Catalog No. T17311Cas No. 2115701-93-2

(+)-JQ1 PA, a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, exhibits an IC50 of 10.4 nM.

Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$98	In Stock
10 mg	$152	In Stock
25 mg	$278	In Stock
50 mg	$396	In Stock
100 mg	$596	In Stock

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Purity:98.36%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	(+)-JQ1 PA, a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, exhibits an IC50 of 10.4 nM.
Targets&IC50	BET:10.4 nM
In vitro	The IC50 of (+)-JQ1 PA for BET is 10.4 nM, and the IC50 of JQ1 is 14.3 nM in MV4;11 cells[1].

Chemical Properties

Molecular Weight	437.95
Formula	C₂₂H₂₀ClN₅OS
Cas No.	2115701-93-2
Smiles	CC=1C2=C(N3C([C@H](CC(NCC#C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 50 mg/mL (114.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.2834 mL	11.4168 mL	22.8337 mL	114.1683 mL
5 mM	0.4567 mL	2.2834 mL	4.5667 mL	22.8337 mL
10 mM	0.2283 mL	1.1417 mL	2.2834 mL	11.4168 mL
20 mM	0.1142 mL	0.5708 mL	1.1417 mL	5.7084 mL
50 mM	0.0457 mL	0.2283 mL	0.4567 mL	2.2834 mL
100 mM	0.0228 mL	0.1142 mL	0.2283 mL	1.1417 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc