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β-Amyloid (1-42), human

Name: β-Amyloid (1-42), human
Brand: TargetMol
SKU: TP1007
Price: 29 USD
Availability: InStock
Rating: 4.5 (1 reviews)

β-Amyloid (1-42), human, is a 42-amino acid peptide integral to the pathogenesis of Alzheimer disease.

Catalog No. TP1007Cas No. 107761-42-2

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Purity:99.52%

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COA HPLC

β-Amyloid (1-42), human

Purity: 99.52%

Catalog No. TP1007Alias β-Amyloid (1-42), human, Amyloid β-Peptide (1-42) humanCas No. 107761-42-2

β-Amyloid (1-42), human, is a 42-amino acid peptide integral to the pathogenesis of Alzheimer disease.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
100 μg	$468	35 days

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Product Introduction

Bioactivity

Description	β-Amyloid (1-42), human, is a 42-amino acid peptide integral to the pathogenesis of Alzheimer disease.
In vitro	Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Application of Amyloid β-Peptide (1-42) human (1 to 10 μM) in the bathing solution does not change delayed rectifier K+-current and leakage current, but enhances inactivation of Са2+-current and blocks Са2+-dependent К+-current[1]. At 2.5 μM concentration, Amyloid β-Peptide (1-42) human reduces viability of SH-SY5Y cells to 65%. Results show that Amyloid β-Peptide (1-42) human localizes in both the cytoplasm and nucleus of SH-SY5Y cells after 30 min of incubation and after 8 h. In the latter, large accumulations of Amyloid β-Peptide (1-42) human are seen in the cytoplasm and in the nucleus. Increased APP mRNA levels are also detected upon Amyloid β-Peptide (1-42) human treatment[2].
Alias	β-Amyloid (1-42), human, Amyloid β-Peptide (1-42) human

Chemical Properties

Molecular Weight	4514.04
Formula	C₂₀₃H₃₁₁N₅₅O₆₀S
Cas No.	107761-42-2

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (11.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.2215 mL	1.1077 mL	2.2153 mL	11.0766 mL
5 mM	0.0443 mL	0.2215 mL	0.4431 mL	2.2153 mL
10 mM	0.0222 mL	0.1108 mL	0.2215 mL	1.1077 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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