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Compound TPX-0046

🥰Excellent
Catalog No. T67779Cas No. 2411115-73-4

Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.

Compound TPX-0046

Compound TPX-0046

🥰Excellent
Purity: 99.94%
Catalog No. T67779Cas No. 2411115-73-4
Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$76In StockIn Stock
5 mg$143In StockIn Stock
10 mg$212In StockIn Stock
25 mg$340In StockIn Stock
50 mg$461In StockIn Stock
100 mg$592In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
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Product Introduction

Bioactivity
Description
Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.
In vitro
Compound TPX-0046 (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells[1].
In vivo
Compound TPX-0046 (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice[1].
Chemical Properties
Molecular Weight424.43
FormulaC21H21FN6O3
Cas No.2411115-73-4
SmilesC[C@H]1CNC(=O)C2=C3N=C4C(=CN3N=C2)O[C@H]5CCC[C@H]5N4CC6=C(O1)N=CC(=C6)F
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: Slightly soluble

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

RETcRETCompoundTPX0046Compound TPX-0046Compound TPX0046Compound TPX 0046
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