Shopping Cart

Your shopping cart is currently empty

Benzyl-α-GalNAc

Name: Benzyl-α-GalNAc
Brand: TargetMol
SKU: T12282
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: O-glycosylation-IN-1) Copy Product Info

😃Good

Synonyms: O-glycosylation-IN-1

Catalog No. T12282 Copy Product Info

Purity: 99.84%

😃Good

Benzyl-α-GalNAc (O-glycosylation-IN-1) is an effective inhibitor of O-glycosylation used to reduce the levels of mucin on the cell surface; it can inhibit the synthesis of O-glycosylated mucin in a human pancreatic cancer cell model. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and suppresses the expression of collagen I/III, making it suitable for studies on liver fibrosis. Benzyl-α-GalNAc can be used in research on glycobiology, tumor metastasis, liver fibrosis, and chemotherapeutic sensitization.

Cas No. 3554-93-6

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
5 mg	$40	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$129	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$328	In Stock	In Stock
200 mg	$492	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.84%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Benzyl-α-GalNAc (O-glycosylation-IN-1) is an effective inhibitor of O-glycosylation used to reduce the levels of mucin on the cell surface; it can inhibit the synthesis of O-glycosylated mucin in a human pancreatic cancer cell model. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and suppresses the expression of collagen I/III, making it suitable for studies on liver fibrosis. Benzyl-α-GalNAc can be used in research on glycobiology, tumor metastasis, liver fibrosis, and chemotherapeutic sensitization.
In vitro	Methods: Benzyl-α-GalNAc (2.5 mM) was added to cerebellar granule neurons from newborn (P5-7) SD rats and incubated for 48 hours. Western blot analysis was performed to validate the salicylate modification level of O-linked glycoproteins in cell lysates using biotinylated PNA. Results: Benzyl-α-GalNAc treatment resulted in a significant increase (>4-fold) in PNA binding in cell lysates, confirming its effective inhibition of O-linked glycosylation. [1]
In vivo	Methods: Male C57BL/6 mice aged 6–8 weeks were fed a high-fat diet (HFD) for 10 weeks to induce a metabolic syndrome-like liver disease (MASLD) model. Following 10 weeks of HFD feeding, mice received consecutive tail vein injections of Benzyl-α-GalNAc (0.5, 1.0, 2.0 mg/mouse) daily for 4 weeks. Results: Benzyl-α-GalNAc dose-dependently reduced total hepatic O-GlcNAc and HNF1α O-GlcNAc levels, decreased serum ALT, AST, and TG levels, and alleviated hepatic lipid deposition, collagen deposition, and HSC activation (α-SMA).[1]
Synonyms	O-glycosylation-IN-1

Chemical Properties

Molecular Weight	311.33
Formula	C₁₅H₂₁NO₆
Cas No.	3554-93-6
Smiles	CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OCc1ccccc1
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (770.89 mM), Sonication is recommended.

H2O: 8.33 mg/mL (26.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2120 mL	16.0601 mL	32.1203 mL	160.6013 mL
5 mM	0.6424 mL	3.2120 mL	6.4241 mL	32.1203 mL
10 mM	0.3212 mL	1.6060 mL	3.2120 mL	16.0601 mL
20 mM	0.1606 mL	0.8030 mL	1.6060 mL	8.0301 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0642 mL	0.3212 mL	0.6424 mL	3.2120 mL
100 mM	0.0321 mL	0.1606 mL	0.3212 mL	1.6060 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

InhibitorinhibitBenzyl-α-GalNAcBenzylαGalNAcBenzyl-alpha-GalNAcBenzyl-a-GalNAcBenzyl α GalNAc

Related Tags: Benzyl-α-GalNAc chemical structure | Benzyl-α-GalNAc in vivo | Benzyl-α-GalNAc in vitro | Benzyl-α-GalNAc formula | Benzyl-α-GalNAc molecular weight