Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YHO-13351 free base is the water-soluble prodrug of YHO-13177 which is an inhibitor of BCRP .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 222.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 556.00 | |
500 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | YHO-13351 free base is the water-soluble prodrug of YHO-13177 which is an inhibitor of BCRP . |
In vivo | In mice, YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of Irinotecan Hydrochloride with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas Irinotecan Hydrochloride alone had little effect in these tumor models[1]. |
Molecular Weight | 483.62 |
Formula | C26H33N3O4S |
CAS No. | 912288-64-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (186.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
YHO-13351 free base 912288-64-3 Membrane transporter/Ion channel BCRP YHO-13351 YHO 13351 free base YHO13351 YHO 13351 YHO13351 free base inhibitor inhibit