Powder: -20°C for 3 years
In solvent: -80°C for 2 years
YHO-13351 free base is the water-soluble prodrug of YHO-13177 which is an inhibitor of BCRP .
Description | YHO-13351 free base is the water-soluble prodrug of YHO-13177 which is an inhibitor of BCRP . |
In vivo | In mice, YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of irinotecan with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas irinotecan alone had little effect in these tumor models[1]. |
Molecular Weight | 483.62 |
Formula | C26H33N3O4S |
CAS No. | 912288-64-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 90mg/mL (186.1mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
YHO-13351 free base 912288-64-3 其他 Others YHO 13351 free base YHO13351 free base Inhibitor inhibitor inhibit