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Wighteone

Wighteone
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Purity:98.95%
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Wighteone

Catalog No. TN5254Cas No. 51225-30-0
Wighteone (Erythrinin B) is a small molecule compound derived from Genista ephedroides with potential antifungal and anticancer activity against EGFR L858R/T790M mutant non-small cell lung cancer.
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Pack SizePriceAvailabilityQuantity
2 mg$73In Stock
5 mg$125In Stock
10 mg$208In Stock
25 mg$415In Stock
50 mg$665In Stock
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Product Introduction

Bioactivity
Description
Wighteone (Erythrinin B) is a small molecule compound derived from Genista ephedroides with potential antifungal and anticancer activity against EGFR L858R/T790M mutant non-small cell lung cancer.
In vitro
The limitations of currently available antifungal agents and the rapid emergence of drug-resistant strains necessitate more efficient approaches to screening and developing novel antifungal drugs. METHODS AND RESULTS: The antifungal activity of the natural products of a series of plants was evaluated and Wighteone, 5, 7, 4'-trihydroxy-6-(gamma,gamma-dimethylallyl)isoflavone showed excellent anti-yeast activity (MIC against Saccharomyces cerevisiae was 4 microg/ml). METHODS AND RESULTS: Transcriptome profiling of Wighteone-treated S. cerevisiae indicated that Wighteone is different from commonly used antifungal compounds in its mode of action.
AliasErythrinin B, 6-Isopentenylgenistein
Chemical Properties
Molecular Weight338.35
FormulaC20H18O5
Cas No.51225-30-0
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 80 mg/mL(236.44 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9555 mL14.7776 mL29.5552 mL147.7760 mL
5 mM0.5911 mL2.9555 mL5.9110 mL29.5552 mL
10 mM0.2956 mL1.4778 mL2.9555 mL14.7776 mL
20 mM0.1478 mL0.7389 mL1.4778 mL7.3888 mL
50 mM0.0591 mL0.2956 mL0.5911 mL2.9555 mL
100 mM0.0296 mL0.1478 mL0.2956 mL1.4778 mL

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