Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 36.00 | |
2 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 81.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 207.00 | |
50 mg | In stock | $ 309.00 | |
100 mg | In stock | $ 467.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 85.00 |
Description | WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM). |
Targets&IC50 | HDAC6:0.40 nM |
In vitro | Treatment of anti-multiple myeloma (MM) cell lines with WT161 triggers the accumulation of acetylated tubulin and cell death in MM cell lines more potently than tubacin. Additionally, WT161 in combination with BTZ induces synergistic cytotoxicity and overcomes BTZ resistance in vitro[1]. |
In vivo | WT161 significantly inhibits in vivo MCF7 cell growth, associated with downregulation of ERα, in a murine xenograft model[2]. |
Animal Research | Female NCr nu/nu mice were subcutaneously (sc) implanted with 17?-estradiol-sustained release pellets (0.18 mg, 60 day release time). Mice were inoculated sc with 5 × 10^6 MCF-7 cells suspended in 30% Matrigel. After 1 month of growth, mice with measurable tumors (> 50 mm^3) were assigned into cohorts receiving intraperitoneal WT161 daily (80 mg/kg) or into a control group receiving vehicle alone (10% DMSO, 90% PBS). Caliper measurements of the longest perpendicular tumor diameters were performed every alternate day to estimate the tumor volume, using the formula volume = ? x L x W^2. Animals were sacrificed when tumors reached 2 cm or if the mice appeared moribund. For each animal, relative tumor volume was determined by normalizing data to the baseline tumor volume for that animal at the start of treatment. Statistical significance was determined by 2-way ANOVA analysis[2]. |
Molecular Weight | 458.55 |
Formula | C27H30N4O3 |
CAS No. | 1206731-57-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (218.08 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
WT-161 1206731-57-8 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases Inhibitor inhibit WT161 WT 161 inhibitor