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WT-161

Catalog No. T7385   CAS 1206731-57-8

WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
WT-161 Chemical Structure
WT-161, CAS 1206731-57-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
2 mg In stock $ 52.00
5 mg In stock $ 81.00
10 mg In stock $ 122.00
25 mg In stock $ 207.00
50 mg In stock $ 309.00
100 mg In stock $ 467.00
1 mL * 10 mM (in DMSO) In stock $ 85.00
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Purity: 97.09%
Purity: 95.98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).
Targets&IC50 HDAC6:0.40 nM
In vitro Treatment of anti-multiple myeloma (MM) cell lines with WT161 triggers the accumulation of acetylated tubulin and cell death in MM cell lines more potently than tubacin. Additionally, WT161 in combination with BTZ induces synergistic cytotoxicity and overcomes BTZ resistance in vitro[1].
In vivo WT161 significantly inhibits in vivo MCF7 cell growth, associated with downregulation of ERα, in a murine xenograft model[2].
Animal Research Female NCr nu/nu mice were subcutaneously (sc) implanted with 17?-estradiol-sustained release pellets (0.18 mg, 60 day release time). Mice were inoculated sc with 5 × 10^6 MCF-7 cells suspended in 30% Matrigel. After 1 month of growth, mice with measurable tumors (> 50 mm^3) were assigned into cohorts receiving intraperitoneal WT161 daily (80 mg/kg) or into a control group receiving vehicle alone (10% DMSO, 90% PBS). Caliper measurements of the longest perpendicular tumor diameters were performed every alternate day to estimate the tumor volume, using the formula volume = ? x L x W^2. Animals were sacrificed when tumors reached 2 cm or if the mice appeared moribund. For each animal, relative tumor volume was determined by normalizing data to the baseline tumor volume for that animal at the start of treatment. Statistical significance was determined by 2-way ANOVA analysis[2].
Molecular Weight 458.55
Formula C27H30N4O3
CAS No. 1206731-57-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (218.08 mM)

TargetMolReferences and Literature

1. Hideshima T , Qi J , Paranal R M , et al. Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma[J]. Proceedings of the National Academy of Sciences, 2016:201608067. 2. Hideshima T, Mazitschek R, Qi J,et al.HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer[J].Oncotarget. 2017 Jul 5;8(46):80109-80123.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Reprogramming Compound Library Inhibitor Library NO PAINS Compound Library Epigenetics Compound Library NF-κB Signaling Compound Library Chromatin Modification Compound Library Histone Modification Compound Library

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Keywords

WT-161 1206731-57-8 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases Inhibitor inhibit WT161 WT 161 inhibitor

 

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