Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 191.00 | |
5 mg | In stock | $ 480.00 | |
10 mg | In stock | $ 687.00 | |
25 mg | In stock | $ 1,080.00 | |
50 mg | In stock | $ 1,480.00 |
Description | Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer. |
In vitro | Vorozole inhibits aromatase activity in FSH-stimulated rat granulosa cells with an IC 50 s of 1.4 nM.[3] |
In vivo |
Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 days; Female Sprague-Dawley rats), while displaying an antitumor effect, also elevates serum levels of insulin-like growth factor (IGF)-1 and testosterone.[3] Vorozole (0.8-1.25 mg/kg; p.o.; 5 days; Female Sprague-Dawley rats), in a dose-dependent manner, decreased uterine weight and effectively suppressed tumor aromatase in ovariectomized nude mice.[3] |
Synonyms | R83839, R 83839, R-83839, (+)-Vorozole, R83842 |
Molecular Weight | 324.77 |
Formula | C16H13ClN6 |
CAS No. | 129731-10-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Vorozole 129731-10-8 Endocrinology/Hormones Metabolism Aromatase P450 R-83842 R 83842 R83839 R 83839 R-83839 (+)-Vorozole R83842 inhibitor inhibit