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UNC-2170

Name: UNC-2170
Brand: TargetMol
SKU: T24925
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24925Cas No. 1648707-58-7

Alias UNC-2170, UNC2170, UNC 2170

UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.

UNC-2170

🥰Excellent

Purity: 97.44%

Catalog No. T24925Alias UNC-2170, UNC2170, UNC 2170Cas No. 1648707-58-7

UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$41	-	In Stock
10 mg	$68	-	In Stock
25 mg	$148	-	In Stock
50 mg	$223	-	In Stock
100 mg	$316	-	In Stock
200 mg	$435	-	In Stock
1 mL x 10 mM (in DMSO)	$55	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.44%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.
In vitro	UNC-2170 (500 μM) results in a significant increase in soluble 53BP1 as compared to lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 μM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells[1].
Synonyms	UNC-2170, UNC2170, UNC 2170

Chemical Properties

Molecular Weight	313.23
Formula	C₁₄H₂₁BrN₂O
Cas No.	1648707-58-7
Smiles	CC(C)(C)NCCCNC(=O)c1cccc(Br)c1
Relative Density.	1.233 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/ml (191.55 mM), Sonication is recommended.

Methanol: 125 mg/mL (399.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Methanol

	1mg	5mg	10mg	50mg
1 mM	3.1925 mL	15.9627 mL	31.9254 mL	159.6271 mL
5 mM	0.6385 mL	3.1925 mL	6.3851 mL	31.9254 mL
10 mM	0.3193 mL	1.5963 mL	3.1925 mL	15.9627 mL
20 mM	0.1596 mL	0.7981 mL	1.5963 mL	7.9814 mL
50 mM	0.0639 mL	0.3193 mL	0.6385 mL	3.1925 mL
100 mM	0.0319 mL	0.1596 mL	0.3193 mL	1.5963 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc