Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM. UK-101 has a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer related diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 410.00 | |
5 mg | In stock | $ 963.00 | |
10 mg | In stock | $ 1,290.00 | |
25 mg | In stock | $ 1,860.00 | |
50 mg | In stock | $ 2,380.00 |
Description | UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM. UK-101 has a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer related diseases. |
Targets&IC50 | Immunoproteasome β5:1 μM , LMP2:104 nM , Immunoproteasome β1c:15 μM , LMP2:104 nM, Immunoproteasome β1c:15 μM, Immunoproteasome β5:1 μM |
In vitro | In the G1 phase of the cell cycle, UK-101 (2-8 μM; 24 hours) induces cell cycle arrest and increases the number of the PC-3 cell arrest.UK-101 (1-8 μM; 24 hours) induces cell accumulation in the G1 phase of the cell cycle, it increases p27 accumulation and significantly increases PARP cleavage as a dose-dependent manner.[1] |
In vivo | Tumor volume as a dose-dependent manner decreased by UK-101 (1-3 mg/kg; twice a week; 3 weeks)intraperitoneal injection, it significantly decreases tumor volume at a dose of 3 mg/kg. Additionally, UK-101-treated mice are suffering less systemic toxicity and the weights of mice treated with UK-101 remain steady over the 3-week treatment period.[1] |
Synonyms | UK101, UK 101 |
Molecular Weight | 484.74 |
Formula | C25H48N2O5Si |
CAS No. | 1000313-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (103.15 mM)
You can also refer to dose conversion for different animals. More
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UK-101 1000313-40-5 Proteases/Proteasome Ubiquitination Proteasome UK101 UK 101 inhibitor inhibit