Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tebipenem Pivoxil (Orapenem) , an orally activity carbapenem antibiotic, is utilized in treating otolaryngologic and respiratory infections.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 101.00 | |
25 mg | In stock | $ 165.00 | |
50 mg | In stock | $ 207.00 | |
100 mg | In stock | $ 369.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | Tebipenem Pivoxil (Orapenem) , an orally activity carbapenem antibiotic, is utilized in treating otolaryngologic and respiratory infections. |
In vitro | Tebipenem Pivoxil has high?intestinal apical membrane permeability due to plural intestinal transport routes, including the uptake transporters such as OATP1A2 and OATP2B1 as well as simple diffusion. [1] Tebipenem Pivoxil is quickly converted to tebipenem?(TBPM), an active form of?Tebipenem Pivoxil. Tebipenem Pivoxil are absorbed quickly, and the bioavailability is 71.4%, 59.1%, 34.8% and 44.9%, respectively, in mouse, rat, dog and monkey. [2] Tebipenem shows the strongest bactericidal activity as early as 2 h after exposure at two times the MIC. Tebipenem shows higher affinities for PBP 1A and PBP 2B, high-molecular-weight enzymes, and for PBP 3, a low-molecular-weight enzyme, than for PBP 2X.?[3] Tebipenem?has a potent?activity?against?Neisseria gonorrhoeae; its?activity?is comparable to it of cefixime that has most potent activity among oral antibiotics. [4] |
In vivo | Tebipenem Pivoxil results in survival rate of 83%, compared with 25% survival for Amoxicillin and 0% survival for controls in animal model of?otitis?media. [5] Tebipenem?exhibits?slow?tight-binding inhibition at low micromolar concentrations versus the chromogenic?substrate?nitrocefin.?Tebipenem?acyl-enzyme complex remains stable for greater than 90 min and exists as mixture of the covalently bound drug and the bound retro-aldol cleavage product. [6] |
Synonyms | ME1211, Orapenem |
Molecular Weight | 497.63 |
Formula | C22H31N3O6S2 |
CAS No. | 161715-24-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 81 mg/mL (162.8 mM)
DMSO: 92 mg/mL (184.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Tebipenem Pivoxil 161715-24-8 Microbiology/Virology Antibiotic Antibacterial broad antibacterial spectrum L 084 penicillin-binding protein inhibit L-084 Inhibitor orally active ME-1211 Haemophilus influenza L084 Bacterial Erythromycin-resistant Streptococcus pneumonia Streptococcus pneumonia ME1211 ME 1211 Orapenem inhibitor