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TM-N1324
🥰Excellent
Catalog No. T17103Cas No. 1144477-35-9
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.
TM-N1324
🥰Excellent
Catalog No. T17103Cas No. 1144477-35-9
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $44 | In Stock | |
| 2 mg | $62 | In Stock | |
| 5 mg | $97 | In Stock | |
| 10 mg | $189 | In Stock | |
| 25 mg | $413 | In Stock | |
| 50 mg | $618 | In Stock | |
| 100 mg | $879 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively. |
| Targets&IC50 | GPR39 with Zn2+ (murine):5 nM (EC50), GPR39 with Zn2+ (human):9 nM (EC50), GPR39 without Zn2+ (murine):180 nM (EC50), GPR39 without Zn2+ (human):280 nM (EC50) |
| In vitro | Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%. TM-N1324 is found to have promising in vitro ADME properties. TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0)[1]. |
| Molecular Weight | 397.79 |
| Formula | C18H13ClFN7O |
| Cas No. | 1144477-35-9 |
| Smiles | Cc1nn(c2NC(=O)CC(c12)c1ccc(F)cc1Cl)-c1ncnc2[nH]cnc12 |
| Relative Density. | 1.74 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (25.14 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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