Powder: -20°C for 3 years
In solvent: -80°C for 2 years
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.
Description | TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively. |
Targets&IC50 | murine GPR39 with Zn2+:5 nM (EC50), human GPR39 with Zn2+:9 nM (EC50), murine GPR39 without Zn2+:180 nM (EC50), human GPR39 without Zn2+:280 nM (EC50) |
In vitro | Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%. TM-N1324 is found to have promising in vitro ADME properties. TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0)[1]. |
Molecular Weight | 397.79 |
Formula | C18H13ClFN7O |
CAS No. | 1144477-35-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 10 mg/mL (25.14 mM), Need ultrasonic and warming
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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TM-N1324 1144477-35-9 G蛋白偶联受体 其他 GHSR Others TM-N-1324 TM N1324 Growth hormone secretagogue receptor TMN1324 Inhibitor inhibit inhibitor