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TM-N1324

Catalog No. T17103 CAS 1144477-35-9

TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.

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TM-N1324, CAS 1144477-35-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.
Targets&IC50	murine GPR39 with Zn2+:5 nM (EC50), human GPR39 with Zn2+:9 nM (EC50), murine GPR39 without Zn2+:180 nM (EC50), human GPR39 without Zn2+:280 nM (EC50)
In vitro	Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%. TM-N1324 is found to have promising in vitro ADME properties. TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0)[1].

Molecular Weight	397.79
Formula	C18H13ClFN7O
CAS No.	1144477-35-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mg/mL (25.14 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Frimurer TM, et al. Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions. J Med Chem. 2017 Feb 9;60(3):886-898.

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Keywords

TM-N1324 1144477-35-9 G蛋白偶联受体其他 GHSR Others TM-N-1324 TM N1324 Growth hormone secretagogue receptor TMN1324 Inhibitor inhibit inhibitor

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