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TH-257

Name: TH-257
Brand: TargetMol
SKU: T7128
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7128Cas No. 2244678-29-1

Alias TH 257

TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).

TH-257

🥰Excellent

Purity: 98.23%

Catalog No. T7128Alias TH 257Cas No. 2244678-29-1

TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).

Pack Size	Price	Availability
5 mg	$35	In Stock
10 mg	$56	In Stock
25 mg	$112	In Stock
50 mg	$193	In Stock
100 mg	$313	In Stock
200 mg	$455	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock

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Batch Information

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Purity:98.23%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).
Targets&IC50	LIMK2:39 nM, LIMK1:84 nM
Synonyms	TH 257

Chemical Properties

Molecular Weight	422.54
Formula	C₂₄H₂₆N₂O₃S
Cas No.	2244678-29-1
Smiles	CCCCN(Cc1ccccc1)C(=O)c1ccc(cc1)S(=O)(=O)Nc1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (591.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3666 mL	11.8332 mL	23.6664 mL	118.3320 mL
5 mM	0.4733 mL	2.3666 mL	4.7333 mL	23.6664 mL
10 mM	0.2367 mL	1.1833 mL	2.3666 mL	11.8332 mL
20 mM	0.1183 mL	0.5917 mL	1.1833 mL	5.9166 mL
50 mM	0.0473 mL	0.2367 mL	0.4733 mL	2.3666 mL
100 mM	0.0237 mL	0.1183 mL	0.2367 mL	1.1833 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc