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TH-257

Catalog No. T7128 CAS 2244678-29-1

Synonyms: TH 257

TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TH-257, CAS 2244678-29-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 59.00
10 mg	In stock	$ 93.00
25 mg	In stock	$ 187.00
50 mg	In stock	$ 324.00
100 mg	In stock	$ 524.00
1 mL * 10 mM (in DMSO)	In stock	$ 66.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).
Targets&IC50	LIMK1:84 nM, LIMK2:39 nM

Synonyms	TH 257
Molecular Weight	422.54
Formula	C24H26N2O3S
CAS No.	2244678-29-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (591.66 mM)

References and Literature

1. Fabrizio M . Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials[J]. European Journal of Medicinal Chemistry, 2018:S0223523418305075-.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Aging Compound Library Kinase Inhibitor Library Bioactive Compound Library Cell Cycle Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

LY2812223 LX7101 SM1-71 BMS-5 R-10015 T56-LIMKi BMS-3 LIMK-IN-22j

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TH-257 2244678-29-1 Cell Cycle/Checkpoint LIM Kinase LIM Kinase (LIMK) LIMKs Inhibitor inhibit TH 257 TH257 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.