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TH-257

Catalog No. T7128 CAS 2244678-29-1

Synonyms: TH 257

TH 257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).

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TH-257, CAS 2244678-29-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TH 257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).
Targets&IC50	LIMK2:39 nM, LIMK1:84 nM

Synonyms	TH 257
Molecular Weight	422.54
Formula	C24H26N2O3S
CAS No.	2244678-29-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 250 mg/mL (591.66 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Fabrizio M . Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials[J]. European Journal of Medicinal Chemistry, 2018:S0223523418305075-.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library DNA Damage & Repair Compound Library Cell Cycle Compound Library Kinase Inhibitor Library Anti-Aging Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

TH-257 BMS-3 BMS-5 T56-LIMKi LIMK-IN-22j LY2812223 LX7101 R-10015

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TH-257 2244678-29-1 细胞周期 LIM Kinase LIM Kinase (LIMK) LIMKs TH 257 Inhibitor inhibit TH257 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.