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Spiramycin

Catalog No. T0819 CAS 8025-81-8

Synonyms: Espiramicin, Sequamycin, Rovamycin, Provamycin, Formacidine

Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii.

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Spiramycin, CAS 8025-81-8

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 55.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 97.92%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Spiramycin acts by binding to the bacterial 50S ribosomal subunit, thereby inhibiting translocation. Its primary mechanism during translocation involves stimulating the dissociation of peptidyl-tRNA from the ribosome. The compound reduces the protective effect of anisomycin on 23S rRNA nucleotides. Spiramycin exhibits potent antibacterial activity against the genus Prevotella, Streptococcus mitis, Archaea, strains of Porphyromonas, and Bacteroides, with metronidazole enhancing its efficacy. At 30°C, Spiramycin can inhibit protein synthesis in wild-type cells but not kill mutant or wild-type cells. Treating lipopolysaccharide-stimulated human monocytes with Spiramycin and erythromycin increases the total production of IL-6 without affecting TNFα, IL-1α, or IL-1β production. Spiramycin inhibits protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. It dose-dependently inhibits the proliferative response of human mononuclear cells stimulated by pulse-width modulation and polyhydroxyalkanoate esters. Additionally, Spiramycin induces a reduction in tritiated thymidine uptake, suggesting interference with an early stage of the cell cycle.

Synonyms	Espiramicin, Sequamycin, Rovamycin, Provamycin, Formacidine
Molecular Weight	843.07
Formula	C43H74N2O14
CAS No.	8025-81-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 93 mg/mL (110.3 mM)

Ethanol: 93 mg/mL (110.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Poulsen SM, et al. J Mol Biol, 2000, 304(3), 471-481. 2. Brisson-Noël A, et al. J Antimicrob Chemother, 1988, 22, 13-23. 3. Menninger JR, et al. Antimicrob Agents Chemother, 1982, 21(5), 811-818. 4. Roche Y, et al. J Antimicrob Chemother, 1986, 17(2), 195-203. 5. Bailly S, et al. Antimicrob Agents Chemother, 1991, 35(10), 2016-2019. 6. Etewa SE, et al. Assessment of spiramycin-loaded chitosan nanoparticles treatment on acute and chronic toxoplasmosis in mice. J Parasit Dis. 2018 Mar;42(1):102-113.

Citations

1. Li H, Li J, Li J, et al.Carrimycin inhibits coronavirus replication by decreasing the efficiency of programmed–1 ribosomal frameshifting through directly binding to the RNA pseudoknot of viral frameshift-stimulatory element.Acta Pharmaceutica Sinica B.2024

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Anti-Parasitic Compound Library Drug Repurposing Compound Library Antiparasitic Natural Product Library NO PAINS Compound Library Anti-infective Natural Product Library Anti-Infection Compound Library Immunology/Inflammation Compound Library Saccharide and Glycoside Natural Product Library Natural Product Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Spiramycin 8025-81-8 Microbiology/Virology Parasite Antibiotic Antibacterial Espiramicin inhibit Sequamycin Inhibitor Bacterial Rovamycin Provamycin Formacidine inhibitor

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