Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Setmelanotide Acetate is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 134.00 | |
5 mg | In stock | $ 302.00 | |
10 mg | In stock | $ 454.00 | |
25 mg | In stock | $ 819.00 | |
50 mg | In stock | $ 1,226.00 | |
100 mg | In stock | $ 1,839.00 |
Description | Setmelanotide Acetate is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively). |
Targets&IC50 | hMC1R:3.9 nM (ki), hMC4R: 0.27 nM (EC50), hMC3R: 10 nM (ki), hMC5R: 1600 nM (EC50), rMC4R: 2.7 nM (ki), hMC1R:5.8 nM (EC50), hMC4R: 2.1 nM (ki), hMC3R: 5.3nM (EC50), hMC5R: 430 nM (ki), rMC4R:0.28 Nm (EC50) |
In vitro | Melanocortin receptor agonists act in the brain to regulate food intake and body weight and, independently of these actions, affect insulin sensitivity. Setmelanotide exhibits agonist activity to human and rat MC4R(human and rat MC4R with Kis of 2.1 and 2.7 nM and EC50s of 0.27 and 0.28 nM, respectively)[1]. |
In vivo | Inhibition of refeeding after an overnight fast by BIM-22493 is dependent on functional MC4R.glucose homeostasis acutely improved by BIM-22493. BIM-22493(Lepob/Lepob mice) exhibits significantly improved glucose clearance when compared to controls. Chronic BIM-22493 treatment was associated with significantly lower levels of serum insulin, glucose and HOMA-IR values, suggesting an improvement in insulin sensitivity[1]. Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model[2]. |
Synonyms | BIM-22493 Acetate, RM-493 Acetate, IRC-022493 Acetate |
Molecular Weight | 1177.35 |
Formula | C51H72N18O11S2 |
CAS No. | T12882L |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 10 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Setmelanotide Acetate(920014-72-8 free base) T12882L GPCR/G Protein Neuroscience Melanocortin Receptor BIM-22493 Acetate Setmelanotide Acetate(920014728 free base) RM-493 Acetate IRC-022493 Acetate Setmelanotide Acetate(920014 72 8 free base) Inhibitor inhibitor inhibit