Home Tools
Log in
Cart

Setmelanotide Acetate(920014-72-8 free base)

Catalog No. T12882L   CAS T12882L
Synonyms: BIM-22493 Acetate, RM-493 Acetate, IRC-022493 Acetate

Setmelanotide Acetate is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Setmelanotide Acetate(920014-72-8 free base), CAS T12882L
Pack Size Availability Price/USD Quantity
1 mg In stock $ 134.00
5 mg In stock $ 302.00
10 mg In stock $ 454.00
25 mg In stock $ 819.00
50 mg In stock $ 1,226.00
100 mg In stock $ 1,839.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 100%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Setmelanotide Acetate is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively).
Targets&IC50 hMC1R:3.9 nM (ki), hMC4R: 0.27 nM (EC50), hMC3R: 10 nM (ki), hMC5R: 1600 nM (EC50), rMC4R: 2.7 nM (ki), hMC1R:5.8 nM (EC50), hMC4R: 2.1 nM (ki), hMC3R: 5.3nM (EC50), hMC5R: 430 nM (ki), rMC4R:0.28 Nm (EC50)
In vitro Melanocortin receptor agonists act in the brain to regulate food intake and body weight and, independently of these actions, affect insulin sensitivity. Setmelanotide exhibits agonist activity to human and rat MC4R(human and rat MC4R with Kis of 2.1 and 2.7 nM and EC50s of 0.27 and 0.28 nM, respectively)[1].
In vivo Inhibition of refeeding after an overnight fast by BIM-22493 is dependent on functional MC4R.glucose homeostasis acutely improved by BIM-22493. BIM-22493(Lepob/Lepob mice) exhibits significantly improved glucose clearance when compared to controls. Chronic BIM-22493 treatment was associated with significantly lower levels of serum insulin, glucose and HOMA-IR values, suggesting an improvement in insulin sensitivity[1]. Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model[2].
Synonyms BIM-22493 Acetate, RM-493 Acetate, IRC-022493 Acetate
Molecular Weight 1177.35
Formula C51H72N18O11S2
CAS No. T12882L

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900. 2. Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62(2):490-7.

Related compound libraries

This product is contained In the following compound libraries:
FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library FDA-Approved Drug Library Approved Drug Library Anti-Cancer Compound Library Cyclic Peptide Library GPCR Compound Library Anti-Cancer Drug Library Peptide Compound Library

Related Products

Related compounds with same targets
HS 014 acetate(207678-81-7 free base) HS024 [D-Trp8]-γ-MSH acetate(321351-81-9 free base) Melanotan (MT)-II ACTH 11-24 acetate(4237-93-8 free base) α-MSH Adrenocorticotropic Hormone (ACTH) (4-10), human Bremelanotide Acetate

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Setmelanotide Acetate(920014-72-8 free base) T12882L GPCR/G Protein Neuroscience Melanocortin Receptor BIM-22493 Acetate Setmelanotide Acetate(920014728 free base) RM-493 Acetate IRC-022493 Acetate Setmelanotide Acetate(920014 72 8 free base) Inhibitor inhibitor inhibit