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Schisantherin D

Catalog No. TN2186 CAS 64917-82-4

Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.

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Schisantherin D, CAS 64917-82-4

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5 mg	Inquiry	$ 620.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 940.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
Targets&IC50	HIV:0.5 μg/mL (EC50)
In vitro	Seven of these compounds (1, 6, 8-12) were active as anti-HIV agents. Gomisin G (11) exhibited the most potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively. Schisantherin D (6), kadsuranin (8), and schisandrin C (10) showed good activity with EC50 values of 0.5, 0.8, and 1.2 micrograms/mL, and TI values of 110, 56, and 33.3, respectively. Ten related synthetic biphenyl compounds, five variously substituted bismethylenedioxy, dimethoxy, and dimethoxycarbonyl isomers (18-22) and five brominated derivatives (23-27) also were evaluated for inhibitory activity against HIV-1 replication in acutely infected H9 cells.

Molecular Weight	520.534
Formula	C29H28O9
CAS No.	64917-82-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues.Bioorg Med Chem. 1997 Aug;5(8):1715-23.

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Keywords

Schisantherin D 64917-82-4 Microbiology/Virology Proteases/Proteasome HIV Protease Inhibitor inhibitor inhibit

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