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SUN 1334H

Catalog No. T13040 CAS 607736-84-5

SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7 nM).

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SUN 1334H, CAS 607736-84-5

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25 mg	6-8 weeks	Inquiry
50 mg	6-8 weeks	Inquiry
100 mg	6-8 weeks	Inquiry

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7 nM).
Targets&IC50	H1 receptor:ki： 9.7 nM
In vitro	In CHO-K1/hERG cells,SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum(IC50 : 0.198 μM)[2].
In vivo	In beagle dogs and ovalbumin-induced rhinitis in guinea pigs, SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal [1]. SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions in skin allergy models. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects[2].

Molecular Weight	489.38
Formula	C23H28Cl2F2N2O3
CAS No.	607736-84-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mandhane SN, et al. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112. 2. Mandhane SN, et al. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. Int Arch Allergy Immunol. 2010;151(1):56-69.

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Keywords

SUN 1334H 607736-84-5 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor inhibitor inhibit

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