Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SI-2 hydrochloride (EPH 116 hydrochloride) is a highly promising inhibitor of SRC-3 SMI: SRC-3 (PPI)(IC50 values of 3-20 nM for breast cancer cell death), with acceptable oral availability.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 65.00 | |
25 mg | In stock | $ 98.00 | |
50 mg | In stock | $ 139.00 |
Description | SI-2 hydrochloride (EPH 116 hydrochloride) is a highly promising inhibitor of SRC-3 SMI: SRC-3 (PPI)(IC50 values of 3-20 nM for breast cancer cell death), with acceptable oral availability. |
Targets&IC50 | Breast cancer cell death:3-20 nM |
In vitro | SI-2 selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3. Breast cancer cell death selectively induced by SI-2 with IC50 of 3-20 nM. SI-2 (100 nM) decreases cell motility, invasion, and tumor metastasis in MDAMB-468 cells[1]. |
In vivo | SI-2 causes minimal acute cardiotoxicity based on a hERG channel blocking assay and an unappreciable chronic toxicity to major organs based on histological analyses. SI-2 is a drug-like molecule and meets all of the criteria of Lipinski’s rule[1]. |
Synonyms | EPH 116 hydrochloride |
Molecular Weight | 301.77 |
Formula | C15H16ClN5 |
CAS No. | 1992052-49-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.5 mg/mL (14.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SI-2 hydrochloride 1992052-49-9 Angiogenesis Tyrosine Kinase/Adaptors Src SI2 Hydrochloride EPH 116 Hydrochloride SI 2 Hydrochloride SI-2 Hydrochloride EPH 116 hydrochloride EPH116 Hydrochloride EPH-116 Hydrochloride inhibitor inhibit