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Ro 41-1049 hydrochloride

Catalog No. T16770 CAS 127917-66-2

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

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Ro 41-1049 hydrochloride Chemical Structure

Ro 41-1049 hydrochloride, CAS 127917-66-2

Pack Size	Availability	Price/USD
2 mg	5 days	$ 38.00
5 mg	5 days	$ 59.00
1 mL * 10 mM (in DMSO)	5 days	$ 63.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

In vivo

Ro 41-1049 (20 mg/kg) pretreatment significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing the formation of 3,4-dihydroxyphenylacetic acid and homovanillic acid. Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion [2].

Molecular Weight	301.77
Formula	C12H13ClFN3OS
CAS No.	127917-66-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32 mg/mL (106.04 mM)

H2O: 25 mg/mL (82.84 mM), Sonification is recommended.

References and Literature

1. Cesura AM, et al. Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A. Mol Pharmacol. 1990 Mar;37(3):358-66. 2. Brannan T, et al. Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: an in vivo study. J Neural Transm Park Dis Dement Sect. 1994;8(1-2):99-105.

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Keywords

Ro 41-1049 hydrochloride 127917-66-2 Metabolism Neuroscience MAO Ro 411049 hydrochloride Ro 41 1049 hydrochloride Ro 41-1049 Hydrochloride inhibitor inhibit

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