Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM). |
Targets&IC50 | 5-HT3:0.16 nM |
In vitro | RG 12915 is a displacer of binding of 5-hydroxytryptamine (5-HT3) binding sites with IC50 value of 0.16 nM, whereas failing to displace binding of ligands for the alpha-1, alpha-2 and beta adrenergic, 5-HT1 or 5-HT2 or cholinergic-muscarinic sites (IC50 values less than 1 μM). |
In vivo | RG 12915 (1 mg/kg, p.o.) is highly protective against cisplatin-induced emesis in the dog. RG 12915 has no significant gastroprokinetic activity in the same species. RG 12915 has a lower ED50 value for attenuating cisplatin-induced emetic episodes in the ferret[1]. |
Molecular Weight | 360.88 |
Formula | C20H25ClN2O2 |
CAS No. | 136174-04-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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RG-12915 136174-04-4 GPCR/G Protein Neuroscience 5-HT Receptor RG12915 RG 12915 inhibitor inhibit