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Pterine-6-carboxylic acid

Catalog No. TN6988   CAS 948-60-7
Synonyms: 6-Carboxypterin

Pterine-6-carboxylic acid is a photodegradation product of folic acid, which can be used as a photosensitive agent to study the molecular mechanism of UVA breaking DNA structure.

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Pterine-6-carboxylic acid, CAS 948-60-7
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pterine-6-carboxylic acid is a photodegradation product of folic acid, which can be used as a photosensitive agent to study the molecular mechanism of UVA breaking DNA structure.
In vitro Pterin-6-carboxylic acid induces DNA photooxidation specifically at consecutive G residues through electron transfer[1]. Pterin-6-carboxylic acid bind to the active site of phosphodiesterase 5 with the binding energy value of -7.1 and 2.05A° 2.23A° when compared with other compound found in the plant. In silico studies hypothesized that pterin-6-carboxylic acid can be an inhibitory agent for PDE5 protein which could be a potential drug candidate for the treatment of erectile dysfunction[2].
Synonyms 6-Carboxypterin
Molecular Weight 207.15
Formula C7H5N5O3
CAS No. 948-60-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: <10mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hirakawa K, et al. Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product. Arch Biochem Biophys. 2003 Feb 15;410(2):261-8. 2. Iheanyichukwu, Wopara, et al. Inhibition of Phosphodiesterase 5 Enzyme by Pterine- 6 Carboxylic Acid from Baphia nitida –Related to Erectile Dysfunction: Computational Kinetic. European journal of medicinal plants (2020): 49-55.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Keywords

Pterine-6-carboxylic acid 948-60-7 DNA Damage/DNA Repair Metabolism PDE DNA 6-Carboxypterin Inhibitor inhibitor inhibit

 

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