Powder: -20°C for 3 years
In solvent: -80°C for 2 years
PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
Description | PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. |
Targets&IC50 | CSF1R:Ki: 5.9 nM, CSF1R:0.016 µM (IC50) |
In vivo | Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1]. |
Synonyms | PLX-5622 |
Molecular Weight | 395.41 |
Formula | C21H19F2N5O |
CAS No. | 1303420-67-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 79 mg/mL (199.79 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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PLX5622 1303420-67-8 Tyrosine Kinase/Adaptors CSF-1R c-Fms PLX 5622 Inhibitor CSF-1 receptor microglial CSF1R PLX-5622 orally pathology inhibit penetrant preceding brain colony stimulating factor 1 receptor elimination inhibitor