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PLX5622

Catalog No. T7100 CAS 1303420-67-8

Synonyms: PLX-5622

PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.

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PLX5622, CAS 1303420-67-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
Targets&IC50	CSF1R:Ki: 5.9 nM, CSF1R:0.016 µM (IC50)
In vivo	Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1].

Synonyms	PLX-5622
Molecular Weight	395.41
Formula	C21H19F2N5O
CAS No.	1303420-67-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 79 mg/mL (199.79 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Rosin JM, Vora SR, Kurrasch DM.Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour[J].Brain Behav Immun. 2018 Oct;73:682-697. 2. Spangenberg E, Severson PL, Hohsfield LA,et al.Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model[J].Nat Commun. 2019 Aug 21;10(1):3758.

Citations

1. Yu Z, Fang X, Liu W, et al. Microglia Regulate Blood–Brain Barrier Integrity via MiR‐126a‐5p/MMP9 Axis during Inflammatory Demyelination. Advanced Science. 2022: 2105442 2. Li C, Wu H, Na H S T, et al. Neuronal-Microglial Liver X receptor β Activating Decrease Neuroinflammation and Chronic Stress-induced Depression-Related Behavior in Mice. Brain Research. 2022: 148112.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PLX5622 1303420-67-8 Tyrosine Kinase/Adaptors CSF-1R c-Fms PLX 5622 Inhibitor CSF-1 receptor microglial CSF1R PLX-5622 orally pathology inhibit penetrant preceding brain colony stimulating factor 1 receptor elimination inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.