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PLX5622

Catalog No. T7100 CAS 1303420-67-8

Synonyms: PLX-5622

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PLX5622, CAS 1303420-67-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 97.00
10 mg	In stock	$ 161.00
25 mg	In stock	$ 324.00
50 mg	In stock	$ 537.00
100 mg	In stock	$ 649.00
500 mg	In stock	$ 1,380.00
1 mL * 10 mM (in DMSO)	In stock	$ 86.00

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Purity: 99.89%

Purity: 99.76%

Purity: 99.41%

Purity: 98.83%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
Targets&IC50	CSF1R:0.016 µM (IC50), CSF1R:Ki: 5.9 nM
In vivo	Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1].

Synonyms	PLX-5622
Molecular Weight	395.41
Formula	C21H19F2N5O
CAS No.	1303420-67-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 79 mg/mL (199.79 mM)

References and Literature

1. Rosin JM, Vora SR, Kurrasch DM.Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour[J].Brain Behav Immun. 2018 Oct;73:682-697. 2. Spangenberg E, Severson PL, Hohsfield LA,et al.Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model[J].Nat Commun. 2019 Aug 21;10(1):3758.

Citations

1. Yu Z, Fang X, Liu W, et al. Microglia Regulate Blood–Brain Barrier Integrity via MiR‐126a‐5p/MMP9 Axis during Inflammatory Demyelination. Advanced Science. 2022: 2105442 2. Li C, Wu H, Na H S T, et al. Neuronal-Microglial Liver X receptor β Activating Decrease Neuroinflammation and Chronic Stress-induced Depression-Related Behavior in Mice. Brain Research. 2022: 148112.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Highly Selective Inhibitor Library Inhibitor Library Kinase Inhibitor Library Drug Repurposing Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Bioactive Compound Library Cytokine Inhibitor Library Orally Active Compound Library

Related Products

Related compounds with same targets

CSF1R-IN-17 Sotuletinib OSI-930 PLX647 c-Fms-IN-3 c-Fms-IN-6 PF 477736 PLX5622 hemifumarate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PLX5622 1303420-67-8 Tyrosine Kinase/Adaptors c-Fms CSF-1R Inhibitor CSF-1 receptor PLX-5622 microglial PLX 5622 CSF1R orally pathology inhibit penetrant preceding brain colony stimulating factor 1 receptor elimination inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.