Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OXFBD04 is a potent and selective BRD4 inhibitor (IC50= 166 nM). OXFBD04 is a potent BET bromodomain ligand and exhibits additional modest affinity for the CREBBP bromodomain. OXFBD04 exhibits anti-cancer activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
2 mg | In stock | $ 169.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 493.00 | |
25 mg | In stock | $ 791.00 | |
50 mg | In stock | $ 1,120.00 | |
100 mg | In stock | $ 1,490.00 | |
500 mg | In stock | $ 2,970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 318.00 |
Description | OXFBD04 is a potent and selective BRD4 inhibitor (IC50= 166 nM). OXFBD04 is a potent BET bromodomain ligand and exhibits additional modest affinity for the CREBBP bromodomain. OXFBD04 exhibits anti-cancer activity. |
Targets&IC50 | BRD4:166 nM |
In vitro | OXFBD04 (0.01-100 μM) inhibits the cell growth of cancer cell lines. In MCF7 breast cancer cells, OXFBD04 (10 µM) induces MYC suppression[1]. |
In vivo | OXFBD04 has optimized physicochemical properties (LE = 0.43; LLE = 5.74; SFI = 5.96), and greater metabolic stability (t1/2 = 388 min, CLint = 3.57 µL/min/mg)[1]. |
Molecular Weight | 296.32 |
Formula | C17H16N2O3 |
CAS No. | 2231747-03-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225mg/mL (759.3mM)
You can also refer to dose conversion for different animals. More
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OXFBD04 2231747-03-6 Chromatin/Epigenetic Epigenetic Reader Domain OXFBD 04 OXFBD-04 inhibitor inhibit