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OXFBD04

Catalog No. T12338   CAS 2231747-03-6

OXFBD04 is a potent and selective BRD4 inhibitor (IC50= 166 nM). OXFBD04 is a potent BET bromodomain ligand and exhibits additional modest affinity for the CREBBP bromodomain. OXFBD04 exhibits anti-cancer activity.

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OXFBD04 Chemical Structure
OXFBD04, CAS 2231747-03-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 116.00
2 mg In stock $ 169.00
5 mg In stock $ 289.00
10 mg In stock $ 493.00
25 mg In stock $ 791.00
50 mg In stock $ 1,120.00
100 mg In stock $ 1,490.00
500 mg In stock $ 2,970.00
1 mL * 10 mM (in DMSO) In stock $ 318.00
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Purity: 98.84%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description OXFBD04 is a potent and selective BRD4 inhibitor (IC50= 166 nM). OXFBD04 is a potent BET bromodomain ligand and exhibits additional modest affinity for the CREBBP bromodomain. OXFBD04 exhibits anti-cancer activity.
Targets&IC50 BRD4:166 nM
In vitro OXFBD04 (0.01-100 μM) inhibits the cell growth of cancer cell lines. In MCF7 breast cancer cells, OXFBD04 (10 µM) induces MYC suppression[1].
In vivo OXFBD04 has optimized physicochemical properties (LE = 0.43; LLE = 5.74; SFI = 5.96), and greater metabolic stability (t1/2 = 388 min, CLint = 3.57 µL/min/mg)[1].
Molecular Weight 296.32
Formula C17H16N2O3
CAS No. 2231747-03-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225mg/mL (759.3mM)

TargetMolReferences and Literature

1. Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compounds Library Max Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Epigenetics Compound Library PPI Inhibitor Library

Related Products

Related compounds with same targets
BET bromodomain inhibitor Naphthol AS-E BMS-986158 3',6-Disinapoylsucrose Alobresib GSK620 NI-57 GNE-272

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Keywords

OXFBD04 2231747-03-6 Chromatin/Epigenetic Epigenetic Reader Domain OXFBD 04 OXFBD-04 inhibitor inhibit

 

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