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Monomethyl lithospermate

Catalog No. TN3323   CAS 933054-33-2
Synonyms: Lithospermic acid monomethyl ester

Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats.

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Monomethyl lithospermate Chemical Structure
Monomethyl lithospermate, CAS 933054-33-2
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Biological Description
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Description Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats.
In vitro Monomethyl lithospermate (5, 10 and 20 μM; 12 h) increases cell viability of SHSY-5Y cells treated with oxygen-glucose deprivation and reperfusion (OGD/R).[1] Monomethyl lithospermate (20 μM; 12 h) reduces cell damage, mitochondrial membrane potential loss, and apoptosis in SHSY-5Y cells after hypoxia, glucose deprivation/reoxygenation.[1] Monomethyl lithospermate (5, 10 and 20 μM; 12 h) reduces ROS and intracellular oxidative stress in SHSY-5Y cells.[1] Monomethyl lithospermate (20 μM; 12 h) activates PI3K/AKT in SHSY-5Y cells.[1]
In vivo Monomethyl lithospermate (72.4 μM/kg; oral; once daily for 14 days) improves neurological function and reduces cerebral infarct size in rats with ischemia-reperfusion (IR) 24 h after middle artery occlusion (MCAO); it can reduce MCAO rats reduce oxidative stress levels and inhibit neuronal apoptosis.[1] Monomethyl lithospermate improves ischemia-reperfusion-induced nerve damage by activating PI3K/AKT.[1]
Synonyms Lithospermic acid monomethyl ester
Molecular Weight 552.48
Formula C28H24O12
CAS No. 933054-33-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Yang F, et al. Monomethyl lithospermate alleviates ischemic stroke injury in middle cerebral artery occlusion mice in vivo and protects oxygen glucose deprivation/reoxygenation induced SHSY-5Y cells in vitro via activation of PI3K/Akt signaling. Front Pharmacol. 2022 Oct 13;13:1024439.

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Keywords

Monomethyl lithospermate 933054-33-2 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt PI3K Lithospermic acid monomethyl ester inhibitor inhibit

 

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