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Menadione bisulfite sodium

Catalog No. T5963 CAS 130-37-0

Synonyms: Sodium menadione bisulfite, Menadione sodium bisulfite, Vitamin K3 sodium bisulfite

Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) is used clinically in China to treat hemorrhagic diseases caused by vitamin K deficiency and globally as a vitamin K supplement.

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Menadione bisulfite sodium Chemical Structure

Menadione bisulfite sodium, CAS 130-37-0

Pack Size	Availability	Price/USD
1 g	In stock	$ 34.00
5 g	In stock	$ 80.00
10 g	In stock	$ 118.00
1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) is used clinically in China to treat hemorrhagic diseases caused by vitamin K deficiency and globally as a vitamin K supplement.

In vitro

MSB inhibited Aβ42 amyloid formation in a dose dependent manner, delayed the secondary structural conversion of Aβ42 from random coil to ordered β-sheet, and attenuated the ability of Aβ42 aggregates to disrupt membranes; moreover, the quinone backbone rather than lipophilicity is esstial for the inhibitory effects of MSB. Next, in cells expressing a pathogenic APP mutation (Osaka mutation) that results in the formation of intraneuronal Aβ oligomers, MSB inhibited the intracellular aggregation of Aβ. Moreover, MSB treatment significantly extended the life span of Caenorhabditis elegans CL2120, a strain that expresses human Aβ42. Together, these results suggest that MSB and its derivatives may be further explored as potential therapeutic agents for the prevention or treatment of Alzheimer's disease(AD)[1].

Synonyms	Sodium menadione bisulfite, Menadione sodium bisulfite, Vitamin K3 sodium bisulfite
Molecular Weight	276.24
Formula	C11H9NaO5S
CAS No.	130-37-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (72.4 mM), Sonication is recommended.

References and Literature

1. Yu Z , Yudan Z , Zhuoyi W , et al. Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-β(1–42)[J]. Biochimica et Biophysica Acta (BBA) - General Subjects, 2018, 1862(10):2226-2235. 2. Astakhova T , Morozov A , Erokhov P , et al. Combined Effect of Bortezomib and Menadione Sodium Bisulfite on Proteasomes of Tumor Cells: The Dramatic Decrease of Bortezomib Toxicity in a Preclinical Trial[J]. Cancers, 2018, 10(10).

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cardiovascular Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Oxidation-Reduction Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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