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Macropa-NH2 hydrochloride

Catalog No. T11938 CAS 2443966-86-5

Macropa-NCS, conjugated to Anti-Human HER2 and the prostate-specific membrane antigen-targeting compound RPS-070, serves as a promising therapeutic radionuclide for soft-tissue metastases treatment. Its precursor, Macropa-NH2 hydrochloride, facilitates its synthesis.

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Macropa-NH2 hydrochloride Chemical Structure

Macropa-NH2 hydrochloride, CAS 2443966-86-5

Pack Size	Availability	Price/USD
25 mg	2-4 weeks	$ 1,810.00
50 mg	2-4 weeks	$ 2,360.00
100 mg	2-4 weeks	$ 3,730.00
200 mg	2-4 weeks	Inquiry
500 mg	2-4 weeks	Inquiry
1 mL * 10 mM (in DMSO)	2-4 weeks	$ 738.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

An 11?4TFA (0.1598 g, 0.16 mmol) and Na2CO3 (0.2540 g, 2.4 mmol) white suspension was refluxed in acetone (10 mL) for 30 minutes, then CSCl2 (305 μL, 85%, Acros Organics) was gradually added. The orange mixture continued to reflux for 3 hours and was concentrated at 30 °C under reduced pressure, yielding a pale-orange solid. This solid was dissolved in 10% ACN/H2O with 0.2% TFA (8 mL total), filtered, and then purified using preparative HPLC (Method C). Pure fractions were combined, concentrated at room temperature (RT) under reduced pressure, and lyophilized. Fractions not immediately concentrated were stored at -80 °C. Isothiocyanate 12 was produced as a white and pale-yellow solid mixture (0.0547 g) and stored at -80 °C with Drierite. A 4.4 mg/mL macropa-NCS stock solution was prepared in 0.1 M pH 9.1 NaHCO3 buffer with 0.154 M NaCl, and stored at -80 °C. To a Tmab portion in saline (74 μL), macropa-NCS (52 μL) and NaHCO3 buffer (266 μL) were added, achieving final concentrations of 5.1 mg/mL for Tmab and 0.59 mg/mL for macropa-NCS. Macropa-NCS was estimated to be in a 16-fold molar excess to Tmab, considering macropa-NCS's molecular weight of 1045.76 g/mol as a tetra-TFA salt[1].

Molecular Weight	584.06
Formula	C26H38ClN5O8
CAS No.	2443966-86-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (142.67 mM), Sonification is recommended.

References and Literature

1. Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14712-14717.

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Keywords

Macropa-NH2 hydrochloride 2443966-86-5 Others MacropaNH2 hydrochloride Macropa-NH-2 hydrochloride Macropa NH2 hydrochloride Macropa-NH2 Hydrochloride inhibitor inhibit

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