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ML334

Catalog No. T12078 CAS 1432500-66-7

Synonyms: LH601A

ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation.

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ML334, CAS 1432500-66-7

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1 mg	In stock	$ 49.00

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Purity: 98.06%

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Chemical Properties

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Description	ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation.
Targets&IC50	Keap1:1 μM (Ki)
In vitro	Treatment of HEK293 cells with ML334 (LH601A; 50-100 μM; 6-16 hours) increases NQO1 and TRX1 mRNA levels by 2 to 3 times at both 6 and 16 hours. Additionally, at 6 hours, ML334 enhances HO-1 mRNA expression by 4 to 7 times, with a relatively smaller change in fold increase observed at 16 hours [2]. ML334 (LH601A; 50-100 μM; 16 hours; HEK293 cells) induces the expression of HO-1 and TRX1 proteins in HEK293 cells [2]. Furthermore, ML334 (LH601A) stimulates the expression and nuclear translocation of NRF2 in HEK293 cells [2].

Synonyms	LH601A
Molecular Weight	446.49
Formula	C26H26N2O5
CAS No.	1432500-66-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (67.19 mM), Sonification is recommended.

Ethanol: 30 mg/mL (67.19 mM), Sonification is recommended.

References and Literature

1. Hu L, et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett. 2013 May 15;23(10):3039-43. 2. Wen X, et al. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol. 2015 Jun;29(6):261-6.

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Keywords

ML334 1432500-66-7 Immunology/Inflammation Nrf2 ML 334 LH601A ML-334 inhibitor inhibit

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