Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 1,480.00 | |
2 mg | In stock | $ 1,990.00 | |
5 mg | In stock | $ 2,960.00 |
Description | Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity. |
Targets&IC50 | RMG2:1.16 nM, RMG1:1.25 nM |
In vitro | Lurbinectedin inhibits RMG1 and RMG2 cell growth (IC50: 1.25 and 1.16 nM, respectively). Lurbinectedin exhibits significant antitumor activity toward chemosensitive and chemoresistant human ovarian clear cell carcinoma (CCC) cells in vitro[1]. Lurbinectedin-DNA adducts in living cells give rise to double-strand breaks, triggering S-phase accumulation, and apoptosis. Lurbinectedin is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumors. The potent cytotoxic activity of Lurbinectedin is ascertained in a 23-cell line panel with a mean GI50 value of 2.7 nM[2]. |
In vivo | Lurbinectedin inhibits tumor growth significantly with no weight loss of treated animals, in four murine xenograft models of human cancer[2]. Mouse CCC cell xenografts show that lurbinectedin significantly inhibits tumor growth. Lurbinectedin plus SN-38 causes a significant synergistic effect[1]. |
Synonyms | PM01183 |
Molecular Weight | 784.87 |
Formula | C41H44N4O10S |
CAS No. | 497871-47-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (19.11 mM)
You can also refer to dose conversion for different animals. More
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Lurbinectedin 497871-47-3 Others DNA/RNA Synthesis inhibit PM-01183 DNA Alkylator/Crosslinker Inhibitor PM01183 PM 01183 inhibitor