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MAPK Raf Locostatin

Locostatin

Catalog No. T8823   CAS 133812-16-5

Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.

Locostatin, CAS 133812-16-5
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5 mg In stock 50.00
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Purity 99.84%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.
Animal Research
Carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and locostatin was injected intraperitoneally. Liver fibrosis was assessed by Masson and Sirius red staining, hydroxyproline (HYP) assay, and collagen percentage area. Collagen I, collagen III, and α-SMA were detected by RT-PCR and western blot. The levels of MMP-13, MMP-2, TIMP-1, and TIMP-2 were estimated by ELISA. Liver inflammation was evaluated by HE staining and immunohistochemistry; liver myeloperoxidase (MPO), superoxide dismutase, and malondialdehyde were measured by ELISA; and cytokines were by Mouse Cytokine Array Q4000[2]
Molecular Weight 245.27
Formula C14H15NO3
CAS No. 133812-16-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 5 mg/ml

ethanol: 10 mg/ml

DMF: 5 mg/ml

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. A M J , Stefania Greco A , B M S I A , et al. Locostatin, a disrupter of Raf kinase inhibitor protein, inhibits extracellular matrix production, proliferation, and migration in human uterine leiomyoma and myometrial cells[J]. Fertility and Sterility, 2016, 106( 6):1530-1538. 2. Junji, Yuzi, Qiu, et al. Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice.[J]. Digestive diseases and sciences, 2019.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library MAPK Inhibitor Library HIF-1 Signaling Pathway Compound Library Anti-Pancreatic Cancer Compound Library

Related Products

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I-49 free base I-37 free base( 2359690-13-2(free base)) Sorafenib Sorafenib tosylate I-37 Regorafenib monohydrate Locostatin Plx-4032

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.