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Lagociclovir

Catalog No. T15704 CAS 92562-88-4

Synonyms: MIV-210

Lagociclovir (MIV-210), a nucleoside analogue, is an antiviral compound available for the treatment of HBV82 that inhibits the replication of wild-type hepatitis B virus (HBV) in human hepatocellular carcinoma cell lines that permanently express HBV.

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Lagociclovir, CAS 92562-88-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 310.00
5 mg	In stock	$ 757.00
10 mg	In stock	$ 1,060.00
25 mg	In stock	$ 1,580.00
50 mg	In stock	$ 2,130.00
1 mL * 10 mM (in DMSO)	In stock	$ 719.00

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Purity: 99.84%

ee: 100%

Purity: 98.90%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lagociclovir (MIV-210), a nucleoside analogue, is an antiviral compound available for the treatment of HBV82 that inhibits the replication of wild-type hepatitis B virus (HBV) in human hepatocellular carcinoma cell lines that permanently express HBV.
Targets&IC50	HBV (3TC-R):8 μM, PMEA-R (HBV):13 μM, HBV (WT):9 μM, HBV (3TC+PMEA-R):15 μM
In vitro	Lagociclovir (FLG) (6 days) exhibited inhibitory activity against 3TC-R HBV, wt HBV, PMEA-R HBV and 3TC+PMEA-R HBV in transiently transfected Huh7 cells with IC50s of 8 ± 3.8, 9 ± 2.5, 13 ± 3.4 and 15 ± 6.8 μM, respectively [1]. Lagociclovir (0-100 μM; 6 days) inhibits the replication of HBV wild-type and drug-resistant mutants in transiently transfected Huh7 cells.[2]
In vivo	Anti-HBV compound Oral administration of MIV-210 (20 or 60 mg/kg; body weight/day) induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period.[1]

Synonyms	MIV-210
Molecular Weight	269.23
Formula	C10H12FN5O3
CAS No.	92562-88-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (92.86 mM)

References and Literature

1. Michalak TI, et al. Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B. Antimicrob Agents Chemother. 2009;53(9):3803-3814. 2. Jacquard AC, et al. In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine. Antimicrob Agents Chemother. 2006;50(3):955-961. 3. De Clercq E. Emerging anti-HIV drugs. Expert Opin Emerg Drugs. 2005;10(2):241-273.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compounds Library Max Anti-Viral Compound Library Clinical Compound Library Bioactive Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lagociclovir 92562-88-4 Microbiology/Virology HBV MIV210 MIV-210 MIV 210 inhibitor inhibit

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