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L-655708

Catalog No. TQ0151   CAS 130477-52-0

L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.

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L-655708 Chemical Structure
L-655708, CAS 130477-52-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 77.00
10 mg In stock $ 127.00
25 mg In stock $ 263.00
50 mg In stock $ 517.00
1 mL * 10 mM (in DMSO) In stock $ 85.00
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Purity: 98.41%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
Targets&IC50 GABAA:0.45 nM (Ki)
In vitro L655708, a potent and selective inverse agonist, targets the benzodiazepine site of GABAA receptors that contain the α5 subunit (Ki = 0.45 nM). It exhibits remarkable selectivity, with a 50-100-fold preference for GABAA receptors containing α1, α2, α3, or α6 subunits when combined with β3 and γ2. In a mouse hippocampal slice model, L655708 enhances long-term potentiation (LTP) and improves spatial learning. Notably, it does so without displaying proconvulsant activity.
In vivo At an intraperitoneal administration of 0.7 mg/kg, L-655708 achieves 60-70% occupancy of α5 GABAA receptors, with minimal binding to GABAA receptors containing α1, α2, and α3 subunits. Furthermore, there are no significant off-target behavioral effects, such as sedation and motor impairment.
Molecular Weight 341.36
Formula C18H19N3O4
CAS No. 130477-52-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (14.65 mM), sonification is recommended.

H2O: Insoluble

TargetMolReferences and Literature

1. Saab BJ, et al. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptorinverse agonist L-655708. Anesthesiology. 2010 Nov;113(5):1061-1071.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library

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Keywords

L-655708 130477-52-0 Membrane transporter/Ion channel Neuroscience GABA Receptor L 655708 L655708 inhibitor inhibit

 

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