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KPT185

Catalog No. T2425 CAS 1333151-73-7

Synonyms: KPT-185, KPT 185

KPT-185 is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

KPT185, CAS 1333151-73-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KPT-185 is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.
Targets&IC50	CRM1:100-500nM
Cell Research	Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference)

Synonyms	KPT-185, KPT 185
Molecular Weight	355.317
Formula	C16H16F3N3O3
CAS No.	1333151-73-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

DMSO: 66 mg/mL (185.8 mM)

Ethanol: 66 mg/mL (185.8 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ranganathan P, et al. Blood. 2012, 120(9), 1765-1773. 2. Zhang K, et al. Gastroenterology. 2013, 144(2), 447-456.

Related Products

Related compounds with same targets

Verdinexor Selinexor (KPT-330) KPT276 KPT185 KPT330,(E)- Leptomycin B CBS9106 Leptomycin A

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KPT185 1333151-73-7 离子通道 CRM1 KPT 185 KPT-185 Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.