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KPT185

Catalog No. T2425   CAS 1333151-73-7
Synonyms: KPT-185, KPT 185

KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.

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KPT185 Chemical Structure
KPT185, CAS 1333151-73-7
Pack Size Availability Price/USD Quantity
25 mg Inquiry $ 107.00
50 mg Inquiry $ 180.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.
Targets&IC50 CRM1:100-500nM
Cell Research Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference)
Synonyms KPT-185, KPT 185
Molecular Weight 355.31
Formula C16H16F3N3O3
CAS No. 1333151-73-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: <1 mg/mL

DMSO: 66 mg/mL (185.8 mM)

Ethanol: 66 mg/mL (185.8 mM)

TargetMolReferences and Literature

1. Ranganathan P, et al. Blood. 2012, 120(9), 1765-1773. 2. Zhang K, et al. Gastroenterology. 2013, 144(2), 447-456.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Preclinical Compound Library Apoptosis Compound Library

Related Products

Related compounds with same targets
CRM1-IN-1 KPT330,(E)- CRM1-IN-2 Verdinexor Leptomycin A Selinexor (KPT-330) KPT276 LFS-1107

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Keywords

KPT185 1333151-73-7 Membrane transporter/Ion channel CRM1 KPT-185 KPT 185 inhibitor inhibit

 

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