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KPT185

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COA HNMR HPLC

KPT185

Catalog No. T2425Cas No. 1333151-73-7

KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.

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Pack Size	Price	Availability
25 mg	$499	Backorder
50 mg	$180	Backorder
1 mL x 10 mM (in DMSO)	$218	In Stock

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Product Introduction

Bioactivity

Description	KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.
Cell Research	Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference)
Alias	KPT-185, KPT 185

Chemical Properties

Molecular Weight	355.31
Formula	C16H16F3N3O3
Cas No.	1333151-73-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: <1 mg/mL

DMSO: 66 mg/mL (185.8 mM)

Ethanol: 66 mg/mL (185.8 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8144 mL	14.0722 mL	28.1444 mL	140.7222 mL
5 mM	0.5629 mL	2.8144 mL	5.6289 mL	28.1444 mL
10 mM	0.2814 mL	1.4072 mL	2.8144 mL	14.0722 mL
20 mM	0.1407 mL	0.7036 mL	1.4072 mL	7.0361 mL
50 mM	0.0563 mL	0.2814 mL	0.5629 mL	2.8144 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4072 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc