Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 115.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 397.00 | |
25 mg | In stock | $ 663.00 | |
50 mg | In stock | $ 945.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 283.00 |
Description | KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria. |
Targets&IC50 | GLUT3:90 nM (IC50), GLUT4:68 nM (IC50), GLUT2:137 nM (IC50), GLUT1:115 nM (IC50) |
In vitro | Patient-derived xenograft models of succinate dehydrogenase A (SDHA)-deficient cancers are specifically sensitive to KL-11743, providing direct evidence that TCA cycle-mutant tumors are vulnerable to GLUT inhibitors in vivo[1]. |
Molecular Weight | 522.6 |
Formula | C30H30N6O3 |
CAS No. | 1369452-53-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (47.84 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KL-11743 1369452-53-8 Metabolism transporter GLUT inhibit Inhibitor GLUT1 GLUT2 KL 11743 GLUT3 KL11743 glucose GLUT4 Glucose transporter inhibitor