Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 145.00 | |
5 mg | In stock | $ 363.00 | |
10 mg | In stock | $ 563.00 | |
25 mg | In stock | $ 891.00 | |
50 mg | In stock | $ 1,230.00 | |
100 mg | In stock | $ 1,670.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 426.00 |
Description | IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases. |
Targets&IC50 | GLS1:31 nM (IC50) |
In vitro | IPN60090 has an IC50 against GLS1 and an EC50 against A549 cell proliferation of <100 nM.[1] |
In vivo |
IPN-60090 (100 mg/kg; oral administration; twice daily; 30 days;) causes tumor growth inhibition. IPN-60090 is robust in vivo target engagement in a dose-dependent manner. The glutamate/glutamine ratios and the free plasma concentrations of IPN-60090 at 4 hours post-dose on both day 4 and day 28 are all decreased.[2] IPN60090 (3 mg/kg; i.v.; 10 mg/kg for p.o.) has excellent pharmacokinetic properties, with CL=4.1 mL/min/kg, t1/2=1 hour, Cmax=19 μM, F%=89%.[2] |
Synonyms | GLS1-IN-1 |
Molecular Weight | 532.52 |
Formula | C24H27F3N8O3 |
CAS No. | 1853164-83-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (51.64 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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IPN60090 1853164-83-6 Metabolism Others transporter IPN-60090 IPN 60090 GLS1-IN-1 inhibitor inhibit