Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2.
Description | Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2. |
In vitro | Hesperin is an active compound in wasabi. Whether Hesperin causes cytotoxicity of HUVECs is determined. To study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs, in subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL. More than 1 μg/mL of Hesperin markedly causes cytotoxicity and morphological alterations[2]. |
In vivo | Wild-type and Nrf2-null mice are fed the following diets for 12 weeks : 1) control diet, 2) high-fat diet (HFD), 3) HFD plus Hesperin (10 mg/kg/day ip), 4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron), 5) HFD/Iron plus Hesperin to determine whether Hesperin ameliorates hepatic steatosis and iron accumulation. Hesperin activates Nrf2 and causes phase II enzyme genes but this induction is absent in Nrf2-null mice, showing that Hesperin is a potential activator of the Nrf2/ARE-dependent detoxification pathway. The HFD enhanced hepatic triglycerides in both genotypes and Hesperin suppress increased hepatic triglycerides in wild-type mice but does not reduce these triglycerides in Nrf2-null mice[1]. |
Molecular Weight | 205.34 |
Formula | C8H15NOS2 |
CAS No. | 4430-35-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 50 mg/mL (243.50 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Hesperin 4430-35-7 免疫与炎症 Nrf2 Inhibitor inhibitor inhibit