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Hesperin

Name: Hesperin
Brand: TargetMol
SKU: T15474
Price: 127 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15474Cas No. 4430-35-7

Alias 6-MSITC, 6MSITC, 6 MSITC

Hesperin (6-MSITC), a flavonoid isolated from orange peel, is a circadian decapping enzyme in plants, inhibiting lipid accumulation and production of reactive oxygen and nitrogen species in 3T3-L1 and RAW264.7 cells.

Hesperin

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Purity: 98%

Catalog No. T15474Alias 6-MSITC, 6MSITC, 6 MSITCCas No. 4430-35-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg（48.70 mM * 100 μL in Ethanol）	$127	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98%

Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Bioactivity

Description	Hesperin (6-MSITC), a flavonoid isolated from orange peel, is a circadian decapping enzyme in plants, inhibiting lipid accumulation and production of reactive oxygen and nitrogen species in 3T3-L1 and RAW264.7 cells.
In vitro	b>METHODS: HUVEC cells were stimulated with TNF-a or thrombin in the presence of Hesperin (0.03, 0.1, 0.3, 1 µg/ml, 4 hours). The effect of Hesperin on VWF release induced by TNF-a and thrombin was studied. RESULTS: Hesperin slightly increased TNF-a-induced TF activity, but at 1 lg/mL (4.88 μM), Hesperin reduced TNF-a- or thrombin-induced TF activity; Hesperin did not change the TF activity of unstimulated HUVECs; indicating that TF activity is inversely proportional to the concentration of Hesperin. [2]
In vivo	b>METHODS: Wild-type and Nrf2-deficient mice were fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus hesperin (10 mg/kg, ip, daily), 4) HFD for 6 weeks followed by HFD supplemented with iron for 6 weeks (HFD/iron), and 5) HFD/iron plus hesperin; to investigate whether hesperin could improve hepatic steatosis and iron accumulation. RESULTS: HFD increased hepatic triglycerides in both genotypes and Hesperi; hesperin suppressed the increase in hepatic triglycerides in wild-type mice but did not reduce triglycerides in Nrf2-deficient mice; hesperin did not block hepatic iron accumulation in either genotype. [1]
Synonyms	6-MSITC, 6MSITC, 6 MSITC

Chemical Properties

Molecular Weight	205.34
Formula	C₈H₁₅NOS₂
Cas No.	4430-35-7
Smiles	O=S(C)CCCCCCN=C=S
Relative Density.	1.12 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (121.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8700 mL	24.3499 mL	48.6997 mL	243.4986 mL
5 mM	0.9740 mL	4.8700 mL	9.7399 mL	48.6997 mL
10 mM	0.4870 mL	2.4350 mL	4.8700 mL	24.3499 mL
20 mM	0.2435 mL	1.2175 mL	2.4350 mL	12.1749 mL
50 mM	0.0974 mL	0.4870 mL	0.9740 mL	4.8700 mL
100 mM	0.0487 mL	0.2435 mL	0.4870 mL	2.4350 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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