Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-dependent manner.GSK J5 increases the mortality rate of schistosomes and decreases the viability of adult worms.GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 472.00 | |
50 mg | In stock | $ 689.00 | |
100 mg | In stock | $ 983.00 | |
500 mg | In stock | $ 1,970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 119.00 |
Description | GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-dependent manner.GSK J5 increases the mortality rate of schistosomes and decreases the viability of adult worms.GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide. |
In vitro | GSK J5 (30 μM; 24-96 h) inhibits schistosomes, (5 and 20 μM; 24 h) also inhibits helminths and promotes small changes in worm motility.[1] |
In vivo | It is worth noting that the injection of GSK-J4 attenuated disease progression in a human AML xenograft mouse model. Treatment with GSK-J4 mainly resulted in the downregulation of DNA replication and cell cycle-related pathways and prevents the expression of HOX, a key cancer gene. ChIP-qPCR verified the increased H3K27me3 enrichment in the HOX gene transcription initiation site [1]. |
Synonyms | GSK-J5, GSKJ5 |
Molecular Weight | 417.5 |
Formula | C24H27N5O2 |
CAS No. | 1394854-51-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.18 mg/mL (10 mM), Sonication is recommended.
Ethanol: < 41.75 mg/mL
You can also refer to dose conversion for different animals. More
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GSK J5 1394854-51-3 Chromatin/Epigenetic Histone Demethylase GSK J-5 GSKJ 5 GSKJ-5 GSK-J5 GSKJ5 inhibitor inhibit