store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
250 μg | 35 days | $ 530.00 | |
1 mg | 35 days | $ 1,360.00 |
Description | Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP. |
In vitro | Multidrug resistance (MDR) presents a significant challenge in cancer chemotherapy, but Fumitremorgin C has shown remarkable efficacy in counteracting this problem by increasing drug accumulation in multidrug-selected cell lines. Specifically, it enhances the effectiveness of doxorubicin, mitoxantrone, and topotecan by reversing mitoxantrone resistance up to 114-fold and doxorubicin resistance 3-fold in MCF-7/mtxR cells. Additionally, in S1M1-3.2 cells, Fumitremorgin C substantially boosts the toxicity of these drugs, demonstrating a 26-fold increase for doxorubicin, 93-fold for mitoxantrone, and 24-fold for topotecan. However, it does not mitigate drug resistance in cells with high levels of Pgp or MRP expression [1]. Notably, Fumitremorgin C virtually eliminates resistance mediated by BCRP in vitro, making it a valuable pharmacological tool for investigating the expression and molecular functionality of this transporter. Furthermore, it significantly raises the toxicity of mitoxantrone and topotecan in vector-transfected MCF-7 cells by 2.5–5.6 fold and reduces the IC50 of topotecan in BCRP-overexpressing cells to levels even lower than those in untreated vector-transfected cells [2]. |
Synonyms | 12α-Fumitremorgin C |
Molecular Weight | 379.45 |
Formula | C22H25N3O3 |
CAS No. | 118974-02-0 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (131.77 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Fumitremorgin C 118974-02-0 Membrane transporter/Ion channel Microbiology/Virology Antibacterial Antibiotic ABC BCRP Breast cancer resistance protein ABCG2 12a-Fumitremorgin C Inhibitor inhibit 12α-Fumitremorgin C Bacterial 12alpha-Fumitremorgin C inhibitor