Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted <a href="/pathway/Apoptosis" style="display: inline; color: #c13a36">Apoptosis</a>, associated with endoplasmic reticulum stress and regulation of MAPKs and <a href="/target/Akt" style="display: inline; color: #c13a36">Akt</a> signaling pathways in HCT 116 human colon carcinoma cells.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | $ 2,080.00 |
Description | Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells. |
In vitro | Flavokawain A, Flavokawain B and Flavokawain C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and Flavokawain B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and Flavokawain C. Flavokawain B also exerts antinociceptive effects as well as antiinflammation properties[1] |
Molecular Weight | 300.31 |
Formula | C17H16O5 |
CAS No. | 56798-34-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Flavokawain C 56798-34-6 Immunology/Inflammation MAPK Neuroscience NADPH-oxidase AChR Inhibitor inhibitor inhibit