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Flavokawain C

Catalog No. TN1645 CAS 56798-34-6

Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted <a href="/pathway/Apoptosis" style="display: inline; color: #c13a36">Apoptosis</a>, associated with endoplasmic reticulum stress and regulation of MAPKs and <a href="/target/Akt" style="display: inline; color: #c13a36">Akt</a> signaling pathways in HCT 116 human colon carcinoma cells.

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Flavokawain C, CAS 56798-34-6

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5 mg	Inquiry	$ 2,080.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.

In vitro

Flavokawain A, Flavokawain B and Flavokawain C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and Flavokawain B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and Flavokawain C. Flavokawain B also exerts antinociceptive effects as well as antiinflammation properties[1]

Molecular Weight	300.31
Formula	C17H16O5
CAS No.	56798-34-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. The flavokawains: uprising medicinal chalconesCancer Cell International 2013, 13:102

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Keywords

Flavokawain C 56798-34-6 Immunology/Inflammation MAPK Neuroscience NADPH-oxidase AChR Inhibitor inhibitor inhibit

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