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FRAX597

Catalog No. T6014 CAS 1286739-19-2

FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).

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FRAX597, CAS 1286739-19-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).
Targets&IC50	PAK2:13 nM, PAK1:8 nM, PAK3:19 nM
Kinase Assay	Determination of Enzyme IC50 Values: IC50 values are determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled-enzyme format, according to the manufacturer's protocol (Z'-LYTE@biochemical assay). Kinase selectivity is determined using both the Z'-LYTE@ and Adapta@ kinase assay format.
Cell Research	30,000 cells/well are plated in 12-well dishes in triplicate. Cell growth media with or without FRAX597 is replaced daily. At indicated time points, cells from individual wells are trypsinized and counted using a Coulter counter.(Only for Reference)

Molecular Weight	558.1
Formula	C29H28ClN7OS
CAS No.	1286739-19-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 11.2 mg/mL (20 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Licciulli S, et al. J Biol Chem. 2013, 288(4), 29105-29114. 2. Chow HY, et al. Oncotarget. 2015, 6(4), 1981-1994. 3. Chow HY, et al. Cancer Res. 2012, 72(22), 5966-5975.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Kinase Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Anti-Aging Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

Fingolimod FRAX486 PF-3758309 IPA-3 ZINC194100678 PF-3758309 hydrochloride AZ13705339 GNE 2861

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FRAX597 1286739-19-2 细胞骨架 PAK FRAX-597 p21 activated kinases FRAX 597 Inhibitor inhibit inhibitor

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