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Ercalcitriol

Catalog No. TQ0216 CAS 60133-18-8

Synonyms: 1α,25-Dihydroxy Vitamin D2

Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2. Ercalcitriol, as the physiological activated form of vitamin D, can strengthen immunity via regulation of cathelicidin antimicrobial peptide (CAMP) and defensin β-4 (DEFB4) genes in normal and transformed cells to combat pathogenic infections.

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Ercalcitriol, CAS 60133-18-8

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1 mg	In stock	$ 97.00
5 mg	In stock	$ 437.00
10 mg	In stock	$ 648.00
25 mg	In stock	$ 987.00
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Purity: 99.02%

Biological Description

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Storage & Solubility Information

Description	Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2. Ercalcitriol, as the physiological activated form of vitamin D, can strengthen immunity via regulation of cathelicidin antimicrobial peptide (CAMP) and defensin β-4 (DEFB4) genes in normal and transformed cells to combat pathogenic infections.
In vivo	Ercalcitriol binds to vitamin D receptor (VDR), a nuclear receptor, activates the interaction between VDR and retinol X receptor (RXR) to form VDR/RXR/ cofactor complex, which binds to Vitamin D response elements in the promoter region of target genes to regulate gene transcription[3].

Synonyms	1α,25-Dihydroxy Vitamin D2
Molecular Weight	428.65
Formula	C28H44O3
CAS No.	60133-18-8

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (105.0 mM)

References and Literature

1. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209. 2. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199 3. Nakane M, et al. Differential effects of Vitamin D analogs on bone formation and resorption. J Steroid Biochem Mol Biol. 2006 Jan;98(1):72-7. 4. Gombart AF, et al. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005 Jul;19(9):1067-77.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Bioactive Compound Library Gut Microbial Metabolite Library Human Metabolite Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ercalcitriol 60133-18-8 Others 1alpha,25-Dihydroxy Vitamin D2 1α,25-Dihydroxy Vitamin D2 1a,25-Dihydroxy Vitamin D2 inhibitor inhibit

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