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Eclalbasaponin I

Catalog No. TN1600   CAS 158511-59-2

Eclalbasaponin I has anti-oxidative, and antitumor activities, it reduces oxidative stress-induced neural cell death by autophagy activation, it can dose-dependently inhibit the proliferation of hepatoma cell smmc-7721 with the IC(50) value of 111.1703 ug/ml.

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Eclalbasaponin I Chemical Structure
Eclalbasaponin I, CAS 158511-59-2
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1 mg In stock $ 88.00
5 mg In stock $ 189.00
10 mg In stock $ 313.00
25 mg In stock $ 528.00
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1 mL * 10 mM (in DMSO) In stock $ 297.00
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Purity: 98.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Eclalbasaponin I has anti-oxidative, and antitumor activities, it reduces oxidative stress-induced neural cell death by autophagy activation, it can dose-dependently inhibit the proliferation of hepatoma cell smmc-7721 with the IC(50) value of 111.1703 ug/ml.
Targets&IC50 Smmc 7721 cells:111.1703 μg/ml (IC50)
In vitro Four fractions (water, 30% ethanol, 60% ethanol and 90% ethanol) were obtained. Four compounds, wedelolactone (I), Eclalbasaponin I (II), luteolin (III) and luteolin-7-O-glucoside (IV) were purified and their structures were identified by the interpretation of spectroscopic analyses including MS, (1)H and (13)C NMR. Antitumor activities of extracts (total fraction), four fractions and the isolated compounds were assessed using hepatoma cell smmc-7721 as an in vitro assay system. The 30% ethanol fraction and Eclalbasaponin I dose-dependently inhibited the proliferation of hepatoma cell smmc-7721 with IC(50) values of 74.2399 and 111.1703 μg/ml, respectively, more strongly compared with 5-fluorouracil positive control group with the IC(50) value of 195.3131 μg/ml. Antitumor activities of other fractions and compounds were lower than positive control.
Source
Molecular Weight 796.98
Formula C42H68O14
CAS No. 158511-59-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (34.51 mM)

TargetMolReferences and Literature

1. Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity.Food Chem Toxicol. 2012 Nov;50(11):4016-22.

Related compound libraries

This product is contained In the following compound libraries:
Natural Product Library for HTS Rare Natural Product Library Traditional Chinese Medicine Monomer Library Terpene Natural Product Library NO PAINS Compound Library Anti-Tumor Natural Product Library Bioactive Compounds Library Max Bioactive Compound Library Chinese Pharmacopoeia Natural Product Library

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