Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor.
Pack Size | Availability | Price/USD | Quantity |
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25 mg | Inquiry | $ 1,520.00 |
Description | EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. |
In vitro | FR-positive KB cells are highly sensitive to EC0489 with an IC50 of 5 nM.The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50). |
In vivo | EC0489, administered at doses of 2, 3, and 4 μmol/kg, exhibits dose-dependent antitumor activity in mouse KB tumor models. Furthermore, EC0489 demonstrates a favorable toxicology profile in rats. |
Molecular Weight | 2550.7 |
Formula | C111H156N22O43S2 |
CAS No. | 1096702-14-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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EC0489 1096702-14-5 Others EC-0489 EC 0489 inhibitor inhibit