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Dodecane is a straight-chain alkane primarily used as a fuel, reference standard substance, and solvent, capable of upregulating TNF-α expression in rat skin irritation.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mL | $90 | - | In Stock |
| Description | Dodecane is a straight-chain alkane primarily used as a fuel, reference standard substance, and solvent, capable of upregulating TNF-α expression in rat skin irritation. |
| In vivo | Methods: Hairless rats (CD HrBi rats) were treated with dodecane (230 μL, topical, single dose, 1 hour) to investigate the effects of dodecane on skin irritation (erythema), transepidermal water loss (TEWL), and expression of interleukin-1α (IL-1α), tumor necrosis factor (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) in the skin and blood. Results: Dodecane induced high transepidermal water loss and increased TNF-α expression in the CD HrBi rat model. [1] |
| Synonyms | Ba 51-090453 |
| Molecular Weight | 170.33 |
| Formula | C12H26 |
| Cas No. | 112-40-3 |
| Smiles | CCCCCCCCCCCC |
| Relative Density. | 0.75 g/cm3 at 25℃ (lit.) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 15 mg/mL (88.06 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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