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Chlorpheniramine maleate

Name: Chlorpheniramine maleate
Brand: TargetMol
SKU: T1553
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1553Cas No. 113-92-8

Alias NCI-C55265, Chlorphenamine maleate

Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma.

Chlorpheniramine maleate

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Purity: 99.98%

Catalog No. T1553Alias NCI-C55265, Chlorphenamine maleateCas No. 113-92-8

Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma.
Targets&IC50	H1 receptor:12 nM
In vitro	Oral administration of Chlorpheniramine (10 mg/kg) can suppress short-term scratching in BALB/c mice experiencing albumin-induced allergic skin irritation and ICR mice injected with histamine subcutaneously. Furthermore, in guinea pigs induced with histamine (ED50=0.17 mg/kg), oral intake of Chlorpheniramine prevents mortality. In rats, a dosage of Chlorpheniramine (20 mg/kg) is capable of blocking the histamine or cholinergic mechanisms that induce rapid eye movement (REM) sleep.
In vivo	Chlorpheniramine inhibits the binding of [3H] mepyramine to guinea pig cortical histamine H1 receptors (IC50=8.8 nM). It reduces ornithine decarboxylase mRNA translation in MCF-7, MDA-MB 231, and Ehrlich cells at a concentration of 250 μM, subsequently inhibiting cell proliferation. Chlorpheniramine displays antimalarial activity against Chloroquine-Sensitive (CQS) Plasmodium falciparum strain D6 (IC50=61.2uM) and Multidrug-Resistant (MDR) strain Dd2 (IC50=3.9uM). Furthermore, it exhibits cytotoxicity in mouse splenic lymphocytes induced by Concanavalin A (IC50=33.4 μM).
Kinase Assay	H1-Antihistaminic Activity: The segments (1 cm) of isolated ileum from guinea pigs are suspended in an organ bath containing Tyrode solution (ventilation, 32 °C). The contractile responses to histamine (0.54 μM) are measured with an isotonic transducer. A set concentration of Chlorpheniramine is added in the organ bath 5 minutes before the addition of histamine. IC50 value of Chlorpheniramine is calculated by the probit methond.
Cell Research	Cells are exposed to various concentrations of Chlorpheniramine for 48 hours. Cells are washed, detached, and counted with a Coulter counter for the determination of cell growth.(Only for Reference)
Synonyms	NCI-C55265, Chlorphenamine maleate

Chemical Properties

Molecular Weight	390.87
Formula	C₂₀H₂₃ClN₂O₄
Cas No.	113-92-8
Smiles	OC(=O)\C=C/C(O)=O.CN(C)CCC(C1=CC=C(Cl)C=C1)C1=NC=CC=C1
Relative Density.	1.107 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (127.92 mM), Sonication is recommended.

DMSO: 100 mg/mL (255.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5584 mL	12.7920 mL	25.5840 mL	127.9198 mL
5 mM	0.5117 mL	2.5584 mL	5.1168 mL	25.5840 mL
10 mM	0.2558 mL	1.2792 mL	2.5584 mL	12.7920 mL
20 mM	0.1279 mL	0.6396 mL	1.2792 mL	6.3960 mL
50 mM	0.0512 mL	0.2558 mL	0.5117 mL	2.5584 mL
100 mM	0.0256 mL	0.1279 mL	0.2558 mL	1.2792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc