store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Censavudine (OBP-601) is a nucleoside analog, a nucleoside reverse transcriptase inhibitor, used for the prevention and treatment of human immunodeficiency virus 1 (HIV-1).Censavudine inhibits HIV-2 and HIV-1. Censavudine inhibits HIV-2 and HIV-1 with EC50 ranges of 30-81 nM and 450-890 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 1,960.00 | |
50 mg | Inquiry | $ 2,550.00 | |
100 mg | Inquiry | $ 3,990.00 |
Description | Censavudine (OBP-601) is a nucleoside analog, a nucleoside reverse transcriptase inhibitor, used for the prevention and treatment of human immunodeficiency virus 1 (HIV-1).Censavudine inhibits HIV-2 and HIV-1. Censavudine inhibits HIV-2 and HIV-1 with EC50 ranges of 30-81 nM and 450-890 nM, respectively. |
Targets&IC50 | HIV-2:30-81 nM (EC50), HIV-2 (ROD9):74 nM(EC50), HIV-1:450-890 nM, HIV-1NL4-3:890 nM(EC50) |
In vitro |
In a single-cycle assay, BMS-986001 demonstrates greater activity against HIV-2ROD9 compared to HIV-1NL4-3. The mean EC50s for BMS-986001 are 74 nM for HIV-2ROD9 and 890 nM for HIV-1NL4-3. In a 4-day infection of an immortalized T cell line (CEMss), HIV-2ROD9 exhibits greater sensitivity to BMS-986001, with a mean EC50 of 0.14 nM, which is 30-fold lower than the EC50 for HIV-1NL4-3 (4.2 nM)[2]. Furthermore, BMS-986001 maintains full activity against HIV-2 variants with genomes encoding the single amino acid changes K65R and Q151M in reverse transcriptase[2]. |
In vivo | Comparing the pharmacokinetic parameters of Censavudine (BMS-986001) at doses ranging from 100 to 750 mg/kg, the dried blood spot (DBS) assay and plasma assay are utilized. Across all dose groups in rats, the ratios of AUC(0-24 h) and Cmax for BMS-986001 in DBS compared to plasma remain consistent at 0.83-0.91 and 0.81-0.97, respectively. The Tmax in rat DBS and plasma also consistently occurs at about 1 h[1]. |
Synonyms | OBP 601, BMS 986001, BMS-986001, OBP601, BMS986001, OBP-601 |
Molecular Weight | 248.23 |
Formula | C12H12N2O4 |
CAS No. | 634907-30-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 5 mg/mL (20.14 mM), Sonication is recommended.
DMSO: 45 mg/mL (181.28 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Censavudine 634907-30-5 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase OBP 601 BMS 986001 BMS-986001 OBP601 BMS986001 OBP-601 inhibitor inhibit