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Censavudine

Name: Censavudine
Brand: TargetMol
SKU: T30791
Price: 128 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30791Cas No. 634907-30-5

Alias OBP-601, OBP601, OBP 601, BMS-986001, BMS986001, BMS 986001

Censavudine (OBP-601) is a nucleoside analog, a nucleoside reverse transcriptase inhibitor, used for the prevention and treatment of human immunodeficiency virus 1 (HIV-1).Censavudine inhibits HIV-2 and HIV-1. Censavudine inhibits HIV-2 and HIV-1 with EC50 ranges of 30-81 nM and 450-890 nM, respectively.

Censavudine

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Purity: 99.89%

Catalog No. T30791Alias OBP-601, OBP601, OBP 601, BMS-986001, BMS986001, BMS 986001Cas No. 634907-30-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$128	-	In Stock
5 mg	$318	-	In Stock
10 mg	$497	-	In Stock
25 mg	$987	-	In Stock
50 mg	$1,630	-	In Stock
100 mg	$2,620	-	In Stock
1 mL x 10 mM (in DMSO)	$348	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Censavudine (OBP-601) is a nucleoside analog, a nucleoside reverse transcriptase inhibitor, used for the prevention and treatment of human immunodeficiency virus 1 (HIV-1).Censavudine inhibits HIV-2 and HIV-1. Censavudine inhibits HIV-2 and HIV-1 with EC50 ranges of 30-81 nM and 450-890 nM, respectively.
Targets&IC50	HIV-2:30-81 nM (EC50), HIV-2 (ROD9):74 nM(EC50), HIV-1:450-890 nM, HIV-1NL4-3:890 nM(EC50)
In vitro	In a single-cycle assay, BMS-986001 demonstrates greater activity against HIV-2ROD9 compared to HIV-1NL4-3. The mean EC50s for BMS-986001 are 74 nM for HIV-2ROD9 and 890 nM for HIV-1NL4-3. In a 4-day infection of an immortalized T cell line (CEMss), HIV-2ROD9 exhibits greater sensitivity to BMS-986001, with a mean EC50 of 0.14 nM, which is 30-fold lower than the EC50 for HIV-1NL4-3 (4.2 nM)[2]. Furthermore, BMS-986001 maintains full activity against HIV-2 variants with genomes encoding the single amino acid changes K65R and Q151M in reverse transcriptase[2].
In vivo	Comparing the pharmacokinetic parameters of Censavudine (BMS-986001) at doses ranging from 100 to 750 mg/kg, the dried blood spot (DBS) assay and plasma assay are utilized. Across all dose groups in rats, the ratios of AUC(0-24 h) and Cmax for BMS-986001 in DBS compared to plasma remain consistent at 0.83-0.91 and 0.81-0.97, respectively. The Tmax in rat DBS and plasma also consistently occurs at about 1 h[1].
Synonyms	OBP-601, OBP601, OBP 601, BMS-986001, BMS986001, BMS 986001

Chemical Properties

Molecular Weight	248.23
Formula	C₁₂H₁₂N₂O₄
Cas No.	634907-30-5
Smiles	[H][C@]1(O[C@](CO)(C=C1)C#C)n1cc(C)c(=O)[nH]c1=O
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 5 mg/mL (20.14 mM), Sonication is recommended.

DMSO: 45 mg/mL (181.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (8.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0285 mL	20.1426 mL	40.2852 mL	201.4261 mL
5 mM	0.8057 mL	4.0285 mL	8.0570 mL	40.2852 mL
10 mM	0.4029 mL	2.0143 mL	4.0285 mL	20.1426 mL
20 mM	0.2014 mL	1.0071 mL	2.0143 mL	10.0713 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0806 mL	0.4029 mL	0.8057 mL	4.0285 mL
100 mM	0.0403 mL	0.2014 mL	0.4029 mL	2.0143 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc