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Cbz-NH-PEG1-CH2COOH

Name: Cbz-NH-PEG1-CH2COOH
Brand: TargetMol
SKU: T17717
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17717Cas No. 1260092-43-0

Cbz-NH-PEG1-CH2COOH, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Cbz-NH-PEG1-CH2COOH

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Purity: 99.26%

Catalog No. T17717Cas No. 1260092-43-0

Cbz-NH-PEG1-CH2COOH, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Pack Size	Price	Availability	Quantity
100 mg	$35	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Batch Information

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Purity:99.26%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Cbz-NH-PEG1-CH2COOH, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.
In vitro	PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase and the other to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs enable the selective degradation of target proteins[2].

Chemical Properties

Molecular Weight	253.25
Formula	C₁₂H₁₅NO₅
Cas No.	1260092-43-0
Smiles	OC(=O)COCCNC(=O)OCc1ccccc1
Relative Density.	1.256 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (394.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9487 mL	19.7433 mL	39.4867 mL	197.4334 mL
5 mM	0.7897 mL	3.9487 mL	7.8973 mL	39.4867 mL
10 mM	0.3949 mL	1.9743 mL	3.9487 mL	19.7433 mL
20 mM	0.1974 mL	0.9872 mL	1.9743 mL	9.8717 mL
50 mM	0.0790 mL	0.3949 mL	0.7897 mL	3.9487 mL
100 mM	0.0395 mL	0.1974 mL	0.3949 mL	1.9743 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc