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CH-223191

Catalog No. T2448   CAS 301326-22-7
Synonyms: CH 223191

CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).

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CH-223191 Chemical Structure
CH-223191, CAS 301326-22-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 56.00
10 mg In stock $ 98.00
25 mg In stock $ 178.00
50 mg In stock $ 296.00
100 mg In stock $ 515.00
200 mg In stock $ 739.00
500 mg In stock $ 1,150.00
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Purity: 99.01%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
Targets&IC50 AhR:30 nM
In vitro Daily oral administration of 10 mg/kg CH-223191 effectively prevents cytochrome P450 induction, wasting syndrome, and hepatotoxicity in mice caused by exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
In vivo CH-223191 downregulates the TGF-β/Smad pathway in human glioblastoma cells, consequently reducing clonogenic survival and invasiveness. In neuron cells derived from human SK-N-SH, it counteracts the suppression of neuronal acetylcholinesterase expression induced by TCDD. Moreover, CH-223191 blocks the nuclear translocation and DNA binding of AhR mediated by TCDD and also inhibits the activation of cytochrome P450 enzyme activity induced by TCDD. Additionally, CH-223191 enhances the expression of ICAM-1 in endothelial cells and prevents the nuclear translocation of RelB.
Synonyms CH 223191
Molecular Weight 333.39
Formula C19H19N5O
CAS No. 301326-22-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 3.3 mg/mL (10 mM)

DMSO: 33.3 mg/mL (100 mM)

TargetMolReferences and Literature

1. Kim SH, et al. Mol Pharmacol. 2006, 69(6), 1871-1878. 2. Gramatzki D, et al. Oncogene. 2009, 28(28), 2593-2605. 3. Xie HQ, et al. Environ Health Perspect. 2013, 121(5), 613-618. 4. de Souza AR, et al. Toxicol Sci. 2014, 140(1), 204-223. 5. Wang K, Lv Q, Miao Y, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway[J]. Biochemical pharmacology. 2018 Sep;155:494-509.

TargetMolCitations

1. Wang K, Lv Q, Miao Y, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. Biochemical Pharmacology. 2018 Sep;155:494-509 2. Zhang F L, Chen X W, Wang Y F, et al.Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2.Journal of Translational Medicine.2023, 21(1): 264.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Anti-Metabolism Disease Compound Library Transcription Factor-Targeted Compound Library Nuclear Receptor Compound Library Target-Focused Phenotypic Screening Library Stem Cell Differentiation Compound Library Bioactive Compounds Library Max Bioactive Compound Library Nonsteroidal Anti-Inflammatory Compound Library Human Metabolite Library

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Keywords

CH-223191 301326-22-7 Immunology/Inflammation Metabolism AhR Aryl Hydrocarbon Receptor Inhibitor inhibit CH223191 CH 223191 inhibitor

 

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